新形式的原纤化纤维素提供了用于食品的改进属性。常规纤维素及其许多衍生物已经被广泛用作食品添加剂,并且在许多国家被授权为安全地用于食品。然而,新形式尚未使用标准化测试方法进行彻底研究。这项研究评估了纤化纤维素的90天饮食毒性,与传统的纤维素相比,索尔卡·弗洛克.SpragueDawley大鼠喂食2%,3%,或4%的原纤化纤维素连续90天,平行SolkaFloc组用作对照。生存,临床观察,体重,食物消费,眼科评估,血液学,血清化学,尿液分析,死后解剖病理学,监测并进行组织病理学检查.没有注意到与原纤化纤维素的施用有关的不利观察。在本研究的条件下,根据评估的毒理学终点,原纤化纤维素的未观察到的不良反应水平(NOAEL)为2194.2mg/kg/天(男性)和2666.6mg/kg/天(女性),对应于雄性和雌性SpragueDawley大鼠的最高测试剂量(4%)。这些结果表明,原纤化纤维素表现类似于常规纤维素,并且当在这些浓度下用作食品成分时不引起安全问题。
Novel forms of fibrillated cellulose offer improved attributes for use in foods. Conventional cellulose and many of its derivatives are already widely used as food additives and are authorized as safe for use in foods in many countries. However, novel forms have not yet been thoroughly investigated using standardized testing methods. This
study assesses the 90-day dietary toxicity of fibrillated cellulose, as compared to a conventional cellulose, Solka Floc. Sprague Dawley rats were fed 2 %, 3 %, or 4 % fibrillated cellulose for 90 consecutive days, and parallel Solka Floc groups were used as controls. Survival, clinical observations, body weight, food consumption, ophthalmologic evaluations, hematology, serum chemistry, urinalysis, post-mortem anatomic pathology, and histopathology were monitored and performed. No adverse observations were noted in relation to the administration of fibrillated cellulose. Under the conditions of this
study and based on the toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) for fibrillated cellulose was 2194.2 mg/kg/day (males) and 2666.6 mg/kg/day (females), corresponding to the highest dose tested (4 %) for male and female Sprague Dawley rats. These results demonstrate that fibrillated cellulose behaves similarly to conventional cellulose and raises no safety concerns when used as a food ingredient at these concentrations.