姜黄素(CUR)作为抗菌剂的使用历史悠久,抗炎和伤口愈合剂,用于治疗各种皮肤状况。纳米载体中的封装可以克服CUR的给药限制,如亲油性和光降解。具有不同基质流动性的脂质纳米载体(固体脂质纳米颗粒;SLN,纳米结构脂质载体;NLC,和纳米乳剂;NE)制备用于姜黄素(CUR)的局部递送。闭塞性能和成膜能力,以及合并的CUR的释放概况,在体外研究了其对光降解和伤口愈合的保护作用,使用空纳米载体或游离CUR作为对照。结果表明,在纳米载体中掺入CUR提供了对光降解的显著保护,其不受基质流动性的影响。然而,这个特征调节着诸如闭塞之类的属性,CUR的释放速率和伤口愈合能力。低流动性的纳米颗粒提供了更好的表面闭塞,成膜能力和保留纳入的CUR。所有纳米载体,尤其是NLC,在较低剂量的纳入CUR下实现了更快的伤口愈合。总之,纳米技术可以增强CUR对皮肤状况的作用。在设计最佳效率的CUR纳米系统时,应考虑纳米载体的重要特性,例如基质流动性。
Curcumin (CUR) has a long history of use as an antimicrobial, anti-inflammatory and wound healing agent, for the treatment of various skin conditions. Encapsulation in nanocarriers may overcome the administration limitations of CUR, such as lipophilicity and photodegradation. Lipid nanocarriers with different matrix fluidity (Solid Lipid Nanoparticles; SLN, Nanostructured Lipid Carriers; NLC, and Nanoemulsion; NE) were prepared for the topical delivery of curcumin (CUR). The occlusive properties and film forming capacity, as well as the release profile of incorporated CUR, its protection against photodegradation and wound healing were studied in vitro, using empty nanocarriers or free CUR as control. The results suggest that incorporation of CUR in nanocarriers offers a significant protection against photodegradation that is not influenced by the matrix fluidity. However, this characteristic regulates properties such as the occlusion, the release rate and wound healing ability of CUR. Nanoparticles of low fluidity provided better surface occlusion, film forming capacity and retention of the incorporated CUR. All nanocarriers but especially NLC, achieved faster wound healing at lower dose of incorporated CUR. In conclusion, nanotechnology may enhance the action of CUR against skin conditions. Important characteristics of the nanocarrier such as matrix fluidity should be taken into consideration in the design of CUR nanosystems of optimal efficiency.