鸽子副粘病毒1(PPMV-1)是禽副粘病毒1的抗原宿主变体。在中国的鸽子中发生了零星的PPMV-1感染暴发;然而,很少有人类PPMV-1感染的报道。本文的目的是报告一例严重的人类PPMV-1感染病例,该患者可能患有COVID-19后综合征(长COVID),并伴有快速进展的肺部感染。该患者是一名66岁的男子,在肺炎发作11天后入住重症监护病房,并在发作64天后康复。PPMV-1从患者的痰液和患者邻居家养的鸽子的泄殖腔涂片中分离出来。在患者的呼吸道和肛门拭子样本中检测到残留的严重急性呼吸综合征冠状病毒2。测序分析表明,PPMV-1基因组属于基因型VI.2.1.1.2.2,在融合蛋白的切割位点具有112RRQKRF117基序,这表明高毒力。这种PPMV-1从鸽子到人类的跨物种传播的情况突出了免疫功能低下患者中严重PPMV-1感染的风险,尤其是那些长有COVID的人。在这一人群中,有必要加强对严重病毒感染风险增加的监测。
Pigeon paramyxovirus 1 (PPMV-1) is an antigenic host variant of avian paramyxovirus 1. Sporadic outbreaks of PPMV-1 infection have occurred in pigeons in China; however, few cases of human PPMV-1 infection have been reported. The purpose of this article is to report a
case of severe human PPMV-1 infection in an individual with probable post-COVID-19 syndrome (long COVID) who presented with rapidly progressing pulmonary infection. The patient was a 66-year-old man who was admitted to the intensive care unit 11 days after onset of pneumonia and recovered 64 days after onset. PPMV-1 was isolated from the patient\'s sputum and in cloacal smear samples from domesticated pigeons belonging to the patient\'s neighbour. Residual severe acute respiratory syndrome coronavirus 2 was detected in respiratory and anal swab samples from the patient. Sequencing analyses revealed that the PPMV-1 genome belonged to genotype VI.2.1.1.2.2 and had the 112RRQKRF117 motif in the cleavage site of the fusion protein, which is indicative of high virulence. This
case of cross-species transmission of PPMV-1 from a pigeon to a human highlights the risk of severe PPMV-1 infection in immunocompromised patients, especially those with long COVID. Enhanced surveillance for increased risk of severe viral infection is warranted in this population.