合成生物学结合了生物学的学科,化学,信息科学,工程,在生物医学中有多种应用,生物能源,环境研究,和其他领域。合成基因组学是合成生物学的一个重要领域,主要包括基因组设计,合成,装配,和转移。基因组转移技术在合成基因组学的发展中发挥了巨大的作用,允许将天然或合成基因组转移到可以轻松修饰基因组的细胞环境中。对基因组转移技术的更全面了解可以帮助将其应用于其他微生物。这里,我们总结了用于微生物基因组转移的三个宿主平台,回顾基因组转移技术的最新进展,并讨论了基因组转移发展的障碍和前景。
Synthetic biology combines the disciplines of biology, chemistry, information science, and engineering, and has multiple applications in biomedicine, bioenergy, environmental studies, and other fields. Synthetic genomics is an important area of synthetic biology, and mainly includes genome design, synthesis, assembly, and transfer. Genome transfer technology has played an enormous role in the development of synthetic genomics, allowing the transfer of natural or synthetic genomes into cellular environments where the genome can be easily modified. A more comprehensive understanding of genome transfer technology can help to extend its applications to other microorganisms. Here, we summarize the three host platforms for microbial genome transfer,
review the recent advances that have been made in genome transfer technology, and discuss the obstacles and prospects for the development of genome transfer.