目的:本文的目的是研究神经源性因子(NGF)及其前体(pro-NGF)的失衡如何介导视网膜神经血管单元(RNVU)的结构和功能损害,在视网膜退行性疾病中起作用。方法:对电子数据库进行文献检索。结果:pro-NGF的促凋亡作用和NGF的促生长作用对RNVU的病理和生理活动至关重要。研究表明，以NGF为基础的视网膜退行性疾病的治疗，包括青光眼,年龄相关性黄斑变性,视网膜色素变性,和糖尿病视网膜病变，取得了显著的疗效。结论：RNVU在视网膜退行性疾病中起着复杂而多方面的作用。生理和病理条件下proNGF-NGF稳态差异信号表达的探索,以及由其调节引起的相应病理过程，这促使我们将重点放在早期视网膜神经保护治疗策略上，以预防视网膜退行性疾病。
Purpose: The purpose of this paper is to investigate how the imbalance of neurogenic factor (NGF) and its precursor (pro-NGF) mediates structural and functional impairment of retinal neurovascular unit (RNVU) that plays a role in retinal degenerative diseases.Methods: A literature search of electronic databases was performed.Results: The pro-apoptotic effect of pro-NGF and the pro-growth effect of NGF are essential for the pathological and physiological activities of RNVU. Studies show that NGF-based treatment of retinal degenerative diseases, including glaucoma, age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy, has achieved remarkable efficacy.Conclusions: RNVU plays a complex and multifaceted role in retinal degenerative diseases. The exploration of the differential signaling expression of proNGF-NGF homeostasis under physiological and pathological conditions, and the corresponding pathological processes induced by its regulation, has prompted us to focus on earlier retinal neuroprotective therapeutic strategies to prevent retinal degenerative diseases.
