■为了研究纹状体棒状杆菌作为医院病原体感染难以愈合的外周伤口,比如皮肤伤口,软组织脓肿和骨髓炎。截至2023年,医学界已收到有关出现全身和中枢感染风险的警报;另一方面,有关外周皮肤区域的文献仍然很少。
■在这项研究中,对两组感染相似病变的患者进行比较:一组存在棒状杆菌,另一个没有。
■总共,从62名患者和131个样品中培养纹状体棒状杆菌。纹状体棒状杆菌感染与以下疾病的存在密切相关:足溃疡;静脉性腿部溃疡;步行改变和/或足负荷改变;外周血管和动脉疾病;住院;恶性肿瘤;脊髓损伤;以及最近使用抗生素(所有关联的p<0.05)。与非纹状体棒状杆菌组患者相比,纹状体棒状杆菌患者的总体生存率较低(28.6对31.6个月,分别为;p=0.0285)。多因素分析显示纹状体棒状杆菌感染是预后不良的独立因素(p<0.0001)。
■鉴于我们的研究结果,纹状体棒状杆菌似乎是感染外周组织并使伤口愈合复杂化的重要机会病原体。鉴于其众多且令人担忧的毒力因素(如多药耐药性和生物膜产生),在医院和门诊环境中,专业伤口护理提供者应特别注意这种病原体。
UNASSIGNED: To investigate Corynebacterium striatum as a nosocomial pathogen infecting hard-to-heal peripheral wounds, such as skin wounds, soft tissue abscesses and osteomyelitis. As of 2023, the medical community were alerted against the risk of emerging systemic and central infections; on the other hand literature on peripheral cutaneous regions is still scarce.
UNASSIGNED: In this
study, two groups of patients with similar lesions which were infected were compared: one group with the presence of the coryneform rod, the other without.
UNASSIGNED: In total, Corynebacterium striatum was cultured from 62 patients and 131 samples. Corynebacterium striatum infection correlated well with the presence of: foot ulcer; venous leg ulcer; altered ambulation and/or altered foot loading; peripheral vascular and arterial disease; hospitalisation; malignancy; spinal cord injury; and recent administration of antibiotics (p<0.05 for all associations). Patients with Corynebacterium striatum had a lower overall survival rate compared to patients in the non-Corynebacterium striatum group (28.6 versus 31.6 months, respectively; p=0.0285). Multivariate analysis revealed that Corynebacterium striatum infection was an independent factor for poor prognosis (p<0.0001).
UNASSIGNED: In view of the findings of our
study, Corynebacterium striatum appears to be an important opportunistic pathogen infecting peripheral tissues and complicating wound healing. Given its numerous and worrying virulence factors (such as multidrug resistance and biofilm production), particular attention should be given to this pathogen by professional wound care providers in nosocomial and outpatient environments.