背景:目的是报告一例罕见的由结核杆菌引起的淋巴结炎,和实验室的应对方法在分离和鉴定这种罕见的病原体,以提高对疾病的认识。
方法:对一名疑似结核性淋巴结炎患者进行淋巴结活检,分离和培养活检组织。
结果:培养物是革兰氏阳性棒状杆菌,通过微生物质谱和16SrRNA基因测序鉴定为结核杆菌。药敏试验表明该药物对达托霉素敏感,多西环素,庆大霉素,利奈唑胺,万古霉素,还有美罗培南,但对环丙沙星耐药,克林霉素,红霉素,利福平,复方磺胺甲恶唑,头孢曲松,还有头孢吡肟.
结论:这是一例硬脂酸结核杆菌感染。在中国,结核杆菌感染的病例报告相对较少。通过案例研究,我们可以为实验室隔离提供帮助,identification,临床诊断,和治疗。
BACKGROUND: The goal was to report a rare
case of lymphadenitis caused by Corynebacterium tuberculostearicum, and the laboratory\'s coping approach in the isolation and identification of this rare pathogen to improve the understanding of the disease.
METHODS: Lymph node biopsy was performed in a patient with suspected tuberculous lymphadenitis, and the biopsy tissue was isolated and cultured.
RESULTS: The culture was Gram positive Corynebacterium, which was identified as Corynebacterium tuberculostearicum by microbial mass spectrometry and 16S rRNA gene sequencing. Antimicrobial susceptibility test showed that the drug was sensitive to daptomycin, doxycycline, gentamicin, linezolid, vancomycin, and meropenem, but resistant to ciprofloxacin, clindamycin, erythromycin, rifampicin, compound sulfamethoxazole, ceftriaxone, and cefepime.
CONCLUSIONS: This is a
case of Corynebacterium tuberculostearicum infection.
Case reports of Corynebacterium tuberculostearicum infection are relatively rare in China. Through
case study, we can provide help for laboratory isolation, identification, clinical diagnosis, and treatment.