OBJECTIVE: To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven-Johnson syndrome (SJS) in line with the new classification system for the first time in the literature.
METHODS: Medical records of patients with LSCD because of SJS were reviewed retrospectively. In addition to demographic data and ophthalmologic or systemic findings, anterior segment photographs of the patients were reviewed retrospectively. Limbal stem-cell deficiency severity was graded according to the classification published by the Limbal Stem Cell Working Group.
RESULTS: Twenty-four eyes of 14 patients with eye involvement secondary to SJS were included in the study. The mean age of the patients was 36.09±16.70 (9-58) years and the female-to-male ratio was 11:3. The anterior segment photographs of the patients were evaluated by two independent masked observers. Limbal stem-cell deficiency severity was graded according to the classification published by Deng et al. Corneal opacity was divided into three stages according to the area of involvement. Corneal opacity was classified as Stage I if the central 5 mm region of the cornea was not affected, as Stage II if the central 5 mm region of the cornea was affected, and as Stage III if the entire corneal surface was affected. Limbal involvement was classified as Stage A if it was below 50%, as Stage B if it was between 50% and 100%, and as Stage C if it was 100%.
CONCLUSIONS: This is the first study in the literature to describe and classify LSCD because of SJS, according to the new LSCD classification. Consistent with the results, LSCD follows a bimodal distribution. Most patients demonstrated severe (Stage III-32.14%) or mild (Stage IA-21.42%) LSCD.

Pediatric keratoplasty is a highly challenging and demanding procedure in children because of various intraoperative morphologic and functional factors and postoperative complications. However, it remains the only way to promote visual development and to avoid corneal blindness in infants and children with corneal opacities. Corneal transplantation in children is different from that in adults in many aspects, such as surgical techniques and clinical evaluation. Besides, it poses more emphases on the perioperative management and the long-term follow-up, because children are less cooperative when examined and are not readily complaining about symptoms. This article is aimed to provide a consensus concerning the indications, preoperative evaluation, surgical procedures and postoperative management regarding pediatric keratoplasty. The consensus, which is based on the results from discussions and consultations among domestic leading researchers and experts with extensive experiences in the related areas, targets to standardize the procedure of pediatric keratoplasty in clinical practice, to minimize the risk of graft failure and to achieve promising outcomes.
儿童角膜移植手术是角膜混浊患儿复明的唯一方法。由于儿童眼部解剖结构和生理发育具有特殊性，故其角膜移植手术的流程和操作，尤其围手术期和术后长期的管理，与成人患者有诸多不同。为了临床规范开展儿童角膜移植手术，提高手术的成功率和远期预后，中华医学会眼科学分会角膜病学组汇集本领域相关专家，参考国内外临床实践经验，结合循证医学证据，在儿童角膜移植手术的适应证、围手术期管理、操作规范及并发症处理等方面形成共识性意见，以供临床眼科医师在相关工作中参考。.

Prosthetic rehabilitation of phthisis bulbi defects is the only treatment option for cosmetic rehabilitation of patients with such defects. Currently, there is no treatment-based classification for prosthetic rehabilitation of patients with phthisis bulbi. Phthisical ocular defects and/or prosthetic rehabilitation were evaluated in an attempt to establish prosthetic guidelines that could be organized into a classification system. Fifty patients who received rehabilitation for phthisis bulbi were reviewed. Phthisis bulbi defects were divided into 4 classes. All the patients had rehabilitation, depending upon the class to which they were assigned. The aim of this treatment-oriented classification system was to organize and define the complex nature of the restorative decision-making process for patients with phthisis bulbi.

Data on eye irritation are generally needed for the hazard identification of chemicals. As the Bovine Corneal Opacity and Permeability (BCOP) test has been accepted by many regulatory agencies for the identification of corrosive and severe ocular irritants since September 2009 (OECD Test Guideline 437, TG 437), we evaluated this alternative method for routine testing at BASF. We demonstrated our technical proficiency by testing the reference standards recommended in TG 437, and 21 additional materials with published BCOP and in vivo data. Our results matched the published in vitro data very well, but with some intentionally selected false negatives (FNs) and false positives (FPs), the concordance was 77% (24/31), with FN and FP rates of 20% (2/10) and 24% (5/21), respectively. In addition, we tested 21 in-house materials, demonstrating the utility of the BCOP assay for our own test material panel. Histopathological assessment of the corneas by light microscopy was also conducted, as this was suggested as a means of improving the identification of FNs. The histopathology corrected the classification of some FNs, but also increased the number of FPs. Parallel to the test method evaluation, we compared three new opacitometer models with the current standard device. We recommend the use of an opacitometer developed in our BASF laboratory, which has certified components and electronic data storage, resulting in what we consider to be excellent sensitivity, stability and reproducibility.

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