Abstract：
OBJECTIVE: To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven-Johnson syndrome (SJS) in line with the new classification system for the first time in the literature.
METHODS: Medical records of patients with LSCD because of SJS were reviewed retrospectively. In addition to demographic data and ophthalmologic or systemic findings, anterior segment photographs of the patients were reviewed retrospectively. Limbal stem-cell deficiency severity was graded according to the classification published by the Limbal Stem Cell Working Group.
RESULTS: Twenty-four eyes of 14 patients with eye involvement secondary to SJS were included in the study. The mean age of the patients was 36.09±16.70 (9-58) years and the female-to-male ratio was 11:3. The anterior segment photographs of the patients were evaluated by two independent masked observers. Limbal stem-cell deficiency severity was graded according to the classification published by Deng et al. Corneal opacity was divided into three stages according to the area of involvement. Corneal opacity was classified as Stage I if the central 5 mm region of the cornea was not affected, as Stage II if the central 5 mm region of the cornea was affected, and as Stage III if the entire corneal surface was affected. Limbal involvement was classified as Stage A if it was below 50%, as Stage B if it was between 50% and 100%, and as Stage C if it was 100%.
CONCLUSIONS: This is the first study in the literature to describe and classify LSCD because of SJS, according to the new LSCD classification. Consistent with the results, LSCD follows a bimodal distribution. Most patients demonstrated severe (Stage III-32.14%) or mild (Stage IA-21.42%) LSCD.
METHODS: Medical records of patients with LSCD because of SJS were reviewed retrospectively. In addition to demographic data and ophthalmologic or systemic findings, anterior segment photographs of the patients were reviewed retrospectively. Limbal stem-cell deficiency severity was graded according to the classification published by the Limbal Stem Cell Working Group.
RESULTS: Twenty-four eyes of 14 patients with eye involvement secondary to SJS were included in the study. The mean age of the patients was 36.09±16.70 (9-58) years and the female-to-male ratio was 11:3. The anterior segment photographs of the patients were evaluated by two independent masked observers. Limbal stem-cell deficiency severity was graded according to the classification published by Deng et al. Corneal opacity was divided into three stages according to the area of involvement. Corneal opacity was classified as Stage I if the central 5 mm region of the cornea was not affected, as Stage II if the central 5 mm region of the cornea was affected, and as Stage III if the entire corneal surface was affected. Limbal involvement was classified as Stage A if it was below 50%, as Stage B if it was between 50% and 100%, and as Stage C if it was 100%.
CONCLUSIONS: This is the first study in the literature to describe and classify LSCD because of SJS, according to the new LSCD classification. Consistent with the results, LSCD follows a bimodal distribution. Most patients demonstrated severe (Stage III-32.14%) or mild (Stage IA-21.42%) LSCD.
摘要：
目的：在文献中首次根据新的分类系统检查和了解Steven-Johnson综合征（SJS）引起的角膜缘干细胞缺乏症（LSCD）。
方法：回顾性分析SJS导致LSCD患者的病历。除了人口统计学数据和眼科或全身性发现外，对患者的眼前段照片进行回顾性分析.根据角膜缘干细胞工作组公布的分类对角膜缘干细胞缺乏的严重程度进行分级。
结果：研究中纳入了14例SJS继发眼部受累患者的24只眼。患者的平均年龄为36.09±16.70（9-58）岁，男女比例为11：3。由两名独立的蒙面观察者评估患者的眼前段照片。根据Deng等人发表的分类对角膜缘干细胞缺乏的严重程度进行分级。角膜混浊根据受累区域分为三个阶段。如果角膜中央5mm区域未受影响，则将角膜混浊分类为I期。作为第二阶段，如果角膜的中央5毫米区域受到影响，如果整个角膜表面受到影响，则作为III期。如果四肢受累低于50%，则被归类为A阶段，作为阶段B，如果它在50%到100%之间，如果是100%，作为阶段C。
结论：这是文献中第一个由于SJS而对LSCD进行描述和分类的研究，根据新的LSCD分类。与结果一致，LSCD遵循双峰分布。大多数患者表现为严重（III-32.14％）或轻度（IA-21.42％）LSCD。
方法：回顾性分析SJS导致LSCD患者的病历。除了人口统计学数据和眼科或全身性发现外，对患者的眼前段照片进行回顾性分析.根据角膜缘干细胞工作组公布的分类对角膜缘干细胞缺乏的严重程度进行分级。
结果：研究中纳入了14例SJS继发眼部受累患者的24只眼。患者的平均年龄为36.09±16.70（9-58）岁，男女比例为11：3。由两名独立的蒙面观察者评估患者的眼前段照片。根据Deng等人发表的分类对角膜缘干细胞缺乏的严重程度进行分级。角膜混浊根据受累区域分为三个阶段。如果角膜中央5mm区域未受影响，则将角膜混浊分类为I期。作为第二阶段，如果角膜的中央5毫米区域受到影响，如果整个角膜表面受到影响，则作为III期。如果四肢受累低于50%，则被归类为A阶段，作为阶段B，如果它在50%到100%之间，如果是100%，作为阶段C。
结论：这是文献中第一个由于SJS而对LSCD进行描述和分类的研究，根据新的LSCD分类。与结果一致，LSCD遵循双峰分布。大多数患者表现为严重（III-32.14％）或轻度（IA-21.42％）LSCD。
