原发性纤毛运动障碍(PCD)是一种罕见的遗传性疾病,如果不及时治疗,会导致明显的发病率和死亡率。PCD的临床表现包括反复呼吸道感染,侧向缺陷,和不孕症,所有这些都是由于睫状运动受损或缺失引起的。PCD的诊断方法可能包括高速视频显微镜,鼻腔一氧化氮水平的测量,和基因检测;然而,不存在单一的明确诊断测试。本研究旨在强调拉丁美洲(中美洲和南美洲,和加勒比海)。为此,我们比较了北美和欧洲对PCD诊断和治疗的建议,发现这些指南中提到的某些诊断工具和治疗方案在许多拉丁美洲国家并不容易获得.
■这篇综述收集了北美的疾病信息,欧洲,和拉丁美洲将指南结果整理成表格,以明确和潜在的干预措施。拉丁美洲的管理信息是从病例报告中推断出来的,由于大多数发现来自北美对PubMed的建议和研究,谷歌学者,还有Scopus.治疗和管理信息基于北美和欧洲标准。在审查的5774份出版物中,只有15篇文章符合纳入标准(重点是PCD管理,同行评审,并位于美国)。在拉丁美洲没有发现PCD的临床指南,但是发现了哥伦比亚和智利关于呼吸管理的建议。拉丁美洲缺乏指导方针可能是由于这些国家对该疾病的资源和研究有限。
■PCD缺少文档,研究,以及关于其在拉丁美洲流行的建议,可能是由于不利的经济条件。这种缺点导致在北美和欧洲获得的诊断测试的机会有限。PICADAR得分,在这次审查中讨论,可以在低收入国家用作这种疾病的筛查工具。
UNASSIGNED: Primary ciliary dyskinesia (PCD) is a rare genetic disorder that can result in significant morbidity and mortality if left untreated. Clinical manifestations of PCD include recurrent respiratory infections, laterality defects, and infertility, all of which arise from impaired or absent ciliary motility. Diagnostic approaches for PCD may include high-speed video microscopy, measurement of nasal nitric oxide levels, and genetic testing; however, no single definitive diagnostic test exists. The present study aims to highlight the lack of standardized diagnostic and treatment guidelines for PCD in Latin America (Central and South America, and the Caribbean). To this effect, we compared North American and European recommendations for the diagnosis and management of PCD and found that certain diagnostic tools and treatment options mentioned in these guidelines are not readily accessible in many Latin American countries.
UNASSIGNED: This
review gathers disease information in North America, Europe, and Latin America organizing guideline results into tables for clarity and potential interventions. Management information for Latin America is inferred from case reports, as most findings are from North American recommendations and studies on PubMed, Google Scholar, and Scopus. Treatment and management information is based on North American and European standards.Among 5,774 publications reviewed, only 15 articles met the inclusion criteria (focused on PCD management, peer-reviewed, and located in America). No clinical guideline for PCD in Latin America was found, but recommendations on respiratory management from Colombia and Chile were discovered. The lack of guidelines in Latin America may originate from limited resources and research on the disease in those countries.
UNASSIGNED: PCD lacks documentation, research, and recommendations regarding its prevalence in Latin America, likely due to unfavorable economic conditions. This disadvantage results in limited access to diagnostic tests available in North America and Europe. The PICADAR score, discussed in this
review, can be used in low-income nations as a screening tool for the disorder.