Chylous ascites

乳糜腹水
  • 文章类型: Case Reports
    乳糜腹膜是指腹腔内存在乳糜。本研究的重点是急性乳糜腹膜,由于文献中报道的病例数量有限,这是一种罕见的疾病,发病率不明确。这里,我们介绍了一名24岁的沙特女性,在腹腔镜阑尾切除术中诊断为乳糜腹膜急性阑尾炎,通过低脂饮食和引流成功治疗,同时进行了文献综述,以阐明该病的病理生理学和治疗策略。对于阑尾炎的急性乳糜腹膜,建议采用保守的治疗方法。包括腹腔引流,需要时进行阑尾切除术,和仔细观察。我们提出的管理策略与文献综述的结果一致,并支持保守管理作为这种罕见疾病的安全有效治疗方式。
    Chyloperitoneum is the presence of chyle in the peritoneal cavity. This study focuses on acute chyloperitoneum, a rare condition with an unclear incidence due to limited number of reported cases in the literature. Here, we present a 24-year-old Saudi female with chyloperitoneum diagnosed intraoperatively during a laparoscopic appendectomy for acute appendicitis that was managed successfully with a low-fat diet and drainage, alongside a literature review to elucidate the condition\'s pathophysiology and therapeutic strategies. A conservative management approach is recommended for acute chyloperitoneum in the context of appendicitis, this includes intraperitoneal drainage, appendectomy when needed, and careful observation. Our proposed management strategy aligns with findings from the literature review and supports conservative management as a safe and effective treatment modality for this rare condition.
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  • 文章类型: Case Reports
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  • 文章类型: Case Reports
    急性乳糜腹膜炎是一种罕见的医学疾病,可以突然发生,导致腹腔内乳糜液积聚。它被认为是特发性的,因为确切的原因往往是未知的。急性乳糜特发性腹膜炎的症状可以模仿其他腹部紧急情况,使得诊断和管理具有挑战性,需要多学科的方法。我们提出了一例急性特发性乳糜腹膜炎感染急腹症的病例报告,如何通过手术成功治疗,并提供有关该主题的现有文献的全面回顾。乳糜腹膜炎是一种罕见的疾病,其临床表现类似于急腹症。有必要进行仔细的探索。紧急剖腹手术用于治疗腹膜炎并寻找和治疗根本原因。
    Acute chylous peritonitis is an uncommon medical condition that can occur suddenly, resulting in the buildup of chylous fluid in the peritoneal cavity. It is considered idiopathic because the exact cause is often unknown. The symptoms of acute chylous idiopathic peritonitis can mimic other abdominal emergencies, making it challenging to diagnose and manage, requiring a multidisciplinary approach. We present a case report of acute idiopathic chylous peritonitis miming acute abdomen, how was successfully treated with surgery, and provide a comprehensive review of the available literature on this topic. Chylous peritonitis is a rare condition whose clinical presentation mimics an acute abdomen. It is necessary to undertake careful exploration. An emergent laparotomy is indicated to treat the peritonitis and search for and treat the underlying cause.
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  • 文章类型: Journal Article
    简介:乳糜腹膜是由淋巴漏入腹腔引起的,导致富含甘油三酯的乳状液积累。诊断可能具有挑战性,死亡率因根本原因而异,肠扭转只是一个潜在的急性原因。尽管它很罕见,我们的系列病例强调乳糜腹膜与非缺血性小肠扭转相关。我们研究的目的包括评估这种关联的发生率以及评估诊断和治疗方法。材料和方法:我们介绍了2例通过对比增强计算机断层扫描(CT)发现的疑似小肠扭转的急性腹膜炎。紧急剖腹手术显示无乳白色液体和肠扭转。此外,我们进行了一项截至2023年10月31日的系统评价,确定了15例先前报道的成人小肠扭转和乳糜腹膜病例(通过PRISMA方案).结论:明确乳糜腹膜的病因机制需要特定的诊断工具。磁共振成像(MRI)可能在非紧急情况下有用,而对比增强CT用于紧急情况。尽管小肠扭转很少引起乳糜腹,及时治疗是必要的。肠扭转决定了肠系膜底部的淋巴流动阻塞,在腹腔内渗出和乳糜堆积。单纯肠扭转可以解决乳糜腹膜而不肠缺血。
    Introduction: Chyloperitoneum arises from lymph leakage into the abdominal cavity, leading to an accumulation of milky fluid rich in triglycerides. Diagnosis can be challenging, and mortality rates vary depending on the underlying cause, with intestinal volvulus being just one potential acute cause. Despite its rarity, our case series highlights chyloperitoneum associated with non-ischemic small bowel volvulus. The aims of our study include assessing the incidence of this association and evaluating diagnostic and therapeutic approaches. Material and Methods: We present two cases of acute abdominal peritonitis with suspected small bowel volvulus identified via contrast-enhanced computed tomography (CT). Emergency laparotomy revealed milky-free fluid and bowel volvulus. Additionally, we conducted a systematic review up to 31 October 2023, identifying 15 previously reported cases of small bowel volvulus and chyloperitoneum in adults (via the PRISMA scheme). Conclusions: Clarifying the etiopathogenetic mechanism of chyloperitoneum requires specific diagnostic tools. Magnetic resonance imaging (MRI) may be useful in non-emergency situations, while contrast-enhanced CT is employed in emergencies. Although small bowel volvulus infrequently causes chyloperitoneum, prompt treatment is necessary. The volvulus determines lymphatic flow obstruction at the base of the mesentery, with exudation and chyle accumulation in the abdominal cavity. Derotation of the volvulus alone may resolve chyloperitoneum without intestinal ischemia.
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  • 文章类型: Case Reports
    背景:乳糜腹水是一种罕见但病态的疾病,在化疗后去除非精原细胞生殖细胞肿瘤的残余肿块。
    方法:我们在此介绍一例20岁的男性,他接受了RPLND手术切除。Cisterna乳糜的病变使手术复杂化。术后过程以乳糜腹水的出现为标志。这种并发症的保守治疗策略是成功的,但只有一个月后。
    乳糜腹水是一种罕见但病态的疾病,在化疗后去除非精原细胞生殖细胞肿瘤的残余肿块。基于高蛋白饮食限制脂肪和中链甘油三酯补充的保守管理,和生长抑素通常是成功的。手术应保留用于难以治疗的情况。
    结论:我们报告了我们成功的管理,我们还利用我们的经验和文献综述分析了不同的管理方案。
    BACKGROUND: Chylous ascites is a rare but morbid condition following removal of residual mass in non-seminomatous germ cell tumours following chemotherapy.
    METHODS: We hereby present the case of a 20-year-old man who had undergone RPLND with complete surgical excision. A lesion of the Cisterna chyli complicated the operation. The post-operative course was marked by the appearance of chylous ascites. The conservative management strategy for this complication was successful, but only after a month.
    UNASSIGNED: Chylous ascites is a rare but morbid condition following removal of residual mass in non-seminomatous germ cell tumours following chemotherapy. Conservative management based on a high-protein diet with fat restriction and medium-chain triglyceride supplementation, and somatostatine are usually successful. Surgery should be reserved for situations that are refractory to treatment.
    CONCLUSIONS: We report our successful management and, we also analysed the different management protocols using our experience and review of the literature.
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  • 文章类型: Systematic Review
    背景:神经母细胞性肿瘤手术切除后的乳糜漏/腹水可能会延迟化疗的开始并恶化预后。先前的研究报道了一个高度可变的发病率和风险因素仍然很大程度上未知。本研究旨在分析乳糜漏和腹水的真实发生率,并试图确定风险因素和最佳治疗策略。
    方法:根据PRISMA指南搜索Medline/Embase数据库。文献综述,病例报告,非英语论文被排除在外。数据是由2位作者选择论文后独立提取的。
    结果:最终分析得出15项研究,其中N=1468名患者。术后记录乳糜腹水171例(12%)。大多数经历乳糜漏的患者都成功地通过引流进行了保守治疗,肠道休息,肠外营养和奥曲肽以及这些治疗方案的可变组合。7/171(4%)患者需要手术探查以控制麻烦的持续性乳糜漏。在风险因素分析中,较高的肿瘤分期与乳糜漏的风险显著相关(P<0.0001),而与肾上腺和非肾上腺肿瘤位置无相关性,INRG风险组和肿瘤侧向性。
    结论:神经母细胞性肿瘤手术后的乳糜渗漏是一种常见的病态并发症,发生在约12%的患者中。较高的INSS肿瘤分期预示着较大的风险。保守治疗策略在大多数情况下似乎是成功的。为了避免这种并发症,特别是对于那些需要广泛的根治性手术包括腹膜后淋巴结切除术的较高肿瘤分期的患者,建议进行细致的肠系膜淋巴结扎术。
    方法:III.
    方法:系统评价。
    BACKGROUND: Chyle leakage/ascites after surgical resection of neuroblastic tumors may delay the start of chemotherapy and worsen prognosis. Previous studies have reported a highly variable incidence and risk factors remain largely unknown. This study aims to analyze the true incidence of chyle leaks and ascites and seeks to identify risk factors and optimal treatment strategies.
    METHODS: Medline/Embase databases were searched according to PRISMA guidelines. Literature reviews, case reports, and non-English papers were excluded. Data were extracted independently following paper selection by 2 authors.
    RESULTS: The final analysis yielded 15 studies with N = 1468 patients. Chylous ascites was recorded postoperatively in 171 patients (12%). Most patients experiencing chyle leaks were successfully treated conservatively with drainage, bowel rest, parenteral nutrition and octreotide with variable combinations of these treatment options. 7/171 (4%) patients required operative exploration to control troublesome persistent chyle leaks. In risk factor analysis, higher tumor stage was significantly associated with the risk of chyle leak (P < 0.0001) whereas no correlation was observed with adrenal vs non-adrenal tumor location, INRG risk groups and tumor laterality.
    CONCLUSIONS: Chyle leakage after surgery for neuroblastic tumors is a common morbid complication occurring in some 12% of patients. Higher INSS tumor stage portends greater risk(s). Conservative therapy strategies appear successful in the majority of cases. To avert this complication meticulous mesenteric lymphatic ligation is recommended especially for those patients with higher tumor stage(s) requiring extensive radical surgery including retroperitoneal lymph node resection.
    METHODS: III.
    METHODS: Systematic review.
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  • 文章类型: Review
    目的:肝移植后无乳糜腹水的乳糜胸少见。我们介绍了2例肝移植后孤立性乳糜胸的病例,并进行了文献复习。
    方法:对腹部手术后乳糜胸病例进行文献复习,并对肝移植相关病例进行分析。人口统计信息,后续结果,讨论了2例活体小儿肝脏移植后乳糜胸的治疗细节。
    结果:一名8个月大的儿童和一名15个月大的儿童患有胆汁淤积性肝病和尿素循环缺陷,分别,接受活体供体左外侧段肝移植。出院后出现乳糜胸的患者接受保守治疗。
    结论:孤立性乳糜胸是腹部手术后罕见的并发症,这大多可以用保守的方法治疗。只有在保守治疗失败的耐药病例中,才应进行介入手术和手术方法。
    Chylothorax without chylous ascites after liver transplant is rare. We present 2 cases of isolated chylothorax after liver transplant and a literature review.
    We compiled a literature review of chylothorax cases after abdominal surgery and analyzed the cases related to liver transplant. The demographic information, follow-up results, and treatment details of our 2 cases of chylothorax after living-donor pediatric livertransplant were discussed.
    An 8-month-old child and a 15-month-old child with cholestatic liver disease and urea cycle defect, respectively, underwent living-donor left lateral segment liver transplant. Patients who presented with chylothorax after discharge were treated conservatively.
    Isolated chylothorax is rare complication after abdominal surgery, which is mostly possible to treat with conservative methods. Interventional procedures and a surgical approach should only be performed in resistant cases when conservative treatment has failed.
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  • 文章类型: Review
    背景乳糜腹水(乳糜腹膜),由腹膜腔淋巴渗漏引起的疾病,在肝硬化患者中很少见,占不到1%的病例。治疗通常包括治疗性穿刺,饮食调整,低脂肪,高蛋白饮食,和中链甘油三酯(MCT)补充。奥利司他,脂肪吸收抑制剂,据报道,在治疗乳糜腹水方面显示出潜在的疗效。案例报告我们详细介绍了一名59岁男性患者因失代偿性肝病和腹水恶化而入院的情况。诊断性穿刺发现乳糜腹水,由3.5mmol/L甘油三酯水平表示。尽管进行了治疗性穿刺,饮食调整,MCT补充剂,螺内酯,和特利加压素用于推测的肝肾综合征,病人的腹水持续两周保持乳糜状态。在服用奥利司他时,观察到腹水体积和乳糜含量显着减少,甘油三酯水平降至0.7mmol/L结论我们的案例说明了奥利司他在治疗肝硬化患者乳糜腹水方面的潜力,仅标记现有文献中报告的第二例此类病例。它鼓励进一步探索奥利司他治疗乳糜腹水的治疗潜力。
    BACKGROUND Chylous ascites (chyloperitoneum), a condition arising from lymphatic leakage in the peritoneal cavity, is rare in liver cirrhosis patients, accounting for less than 1% of cases. Treatment typically involves therapeutic paracentesis, dietary modifications, a low-fat, high-protein diet, and medium-chain triglyceride (MCT) supplementation. Orlistat, a fat absorption inhibitor, has been reported to show potential efficacy in treating chylous ascites. CASE REPORT We detail the case of a 59-year-old male patient admitted for decompensated liver disease and worsening ascites. Diagnostic paracentesis identified chylous ascites, indicated by a 3.5 mmol/L triglyceride level. Despite administering therapeutic paracentesis, dietary modifications, MCT supplementation, Spironolactone, and Terlipressin for a presumed hepatorenal syndrome, the patient\'s ascites remained chylous for two weeks. On administering orlistat, a significant reduction in ascites volume and chylous content was observed, with triglyceride levels dropping to 0.7 mmol/L. CONCLUSIONS Our case illustrates the potential of orlistat in managing chylous ascites in liver cirrhosis patients, marking only the second such case reported in the existing literature. It encourages further exploration of orlistat\'s therapeutic potential in treating chylous ascites.
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  • 文章类型: Case Reports
    乳糜腹水(CA)是腹腔内富含甘油三酸酯的腹膜液的罕见发现。恶性肿瘤,肝硬化,腹部手术后的创伤是成人CA的主要原因。目前,没有已发布的CA管理指南.本报告描述了一名18岁女性在正中弓状韧带综合征(MALS)减压后出现腹痛和腹胀的情况。腹部和骨盆的计算机断层扫描(CT)显示大量腹水,肝脏形态正常。穿刺术和腹水研究对富含甘油三酸酯的乳状液体呈阳性。她最近的MALS减压史表明,急性CA的原因是腹部手术的术后并发症。该病例强调了腹水的多种病因以及在评估成人腹水时仔细的病史和体格检查的重要性。
    Chylous ascites (CA) are a rare finding of triglyceride-rich peritoneal fluid within the abdominal cavity. Malignancy, cirrhosis, and trauma after abdominal surgery are the leading causes of CA in adults. Currently, there are no published guidelines on the management of CA. This report describes a case of an 18-year-old female presenting with abdominal pain and distention following median arcuate ligament syndrome (MALS) decompression. A computed tomography (CT) of the abdomen and pelvis showed large-volume ascites with normal hepatic morphology. Paracentesis and ascitic fluid studies were positive for milky fluid rich in triglyceride. Her recent history of MALS decompression revealed the cause of her acute CA to be a postoperative complication from her abdominal surgery. This case highlights the diverse etiology of ascites and the importance of a careful history and physical examination when evaluating adults with ascites.
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  • 文章类型: Case Reports
    乳糜腹膜(乳糜腹水)是腹膜透析(PD)的罕见并发症。它的原因可能是创伤性和非创伤性的,与肿瘤疾病相关,自身免疫性疾病,腹膜后纤维化,或很少使用钙拮抗剂。我们描述了PD患者中发生的6例乳糜腹膜,这是钙通道阻滞剂使用的后遗症。透析方式是自动PD(两名患者)和连续卧床PD(其余患者)。PD的持续时间从几天到8年不等。所有患者都有混浊的腹膜透析液,以白细胞计数阴性和常见细菌和真菌的无菌培养试验为特征。除了一种情况,钙通道阻滞剂开始后不久出现浑浊的腹膜透析液(马尼地平,n=2;乐卡地平,n=4),并在停药后24-72小时内清除。在一个病例中,恢复了用马尼地平治疗,腹膜透析液再次出现混浊。尽管在大多数情况下,PD流出物的浊度是由于传染性腹膜炎,还有其他不同的原因,包括乳糜腹膜。虽然不常见,这些患者的乳糜腹膜可能继发于钙通道阻滞剂的使用。意识到这种关联可以通过暂停潜在的犯罪药物来迅速解决,避免患者的紧张情况,如住院和侵入性诊断程序。
    Chyloperitoneum (chylous ascites) is a rare complication of peritoneal dialysis (PD). Its causes may be traumatic and nontraumatic, associated with neoplastic disease, autoimmune disease, retroperitoneal fibrosis, or rarely calcium antagonist use. We describe six cases of chyloperitoneum occurring in patients on PD as a sequel to calcium channel blocker use. The dialysis modality was automated PD (two patients) and continuous ambulatory PD (the rest of the patients). The duration of PD ranged from a few days to 8 years. All patients had a cloudy peritoneal dialysate, characterized by a negative leukocyte count and sterile culture tests for common germs and fungi. Except for in one case, the cloudy peritoneal dialysate appeared shortly after the initiation of calcium channel blockers (manidipine, n = 2; lercanidipine, n = 4), and cleared up within 24-72 h after withdrawal of the drug. In one case in which treatment with manidipine was resumed, peritoneal dialysate clouding reappeared. Though turbidity of PD effluent is due in most cases to infectious peritonitis, there are other differential causes including chyloperitoneum. Although uncommon, chyloperitoneum in these patients may be secondary to the use of calcium channel blockers. Being aware of this association can lead to prompt resolution by suspension of the potentially offending drug, avoiding stressful situations for the patient such as hospitalization and invasive diagnostic procedures.
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