研究9p21位点rs10757278多态性与传统危险因素在新疆冠心病发病中的交互作用,中国。
这项病例对照研究连续招募了310名年龄在18-70岁之间的无关的连续冠心病患者。所有研究参与者均于2017年1月至12月在新疆医科大学第一附属医院心脏中心招募。根据美国心脏协会确认冠心病的标准,通过冠状动脉造影(至少一条主要冠状动脉直径狭窄≥50%)确认冠心病患者。从职业人群中随机选择健康受试者,在我院进行体检,并根据年龄(±3岁)和性别与病例相匹配,那些没有心血管疾病病史的人,并在病史查询后选择536例受试者作为对照组,体检,心脏超声,心电图,以及医院的其他血液生化检查。通过努力奖励失衡问卷评估职业压力。进行流行病学调查以收集临床数据。卡方检验,方差分析,并采用二元Logistic回归分析。
病例组和对照组在吸烟方面均有显著差异,饮酒,身体活动,高血压,糖尿病,CHD家族史,体质量指数(BMI)(均P<0.05);CHD患病率与职业紧张无关。2组间职业紧张水平差异无统计学意义(P>0.05);病例组与对照组rs10757278基因型差异有统计学意义;采用二元logistic回归分析评价冠心病的危险因素。在调整了年龄和性别后,发现冠心病的风险效应显着增加与吸烟有关[优势比(OR)=2.311;95%置信区间(CI):1.04-2.499;P<0.001],体育锻炼(OR=1.365;95%CI:1.137-1.639;P<0.001),高血压(OR=4.627;95%CI:2.165-10.764;P<0.001),冠心病家族史(OR=4.103;95%CI:3.169-6.892;P<0.001),BMI(OR=2.484;95%CI:2.036-3.03;P<0.001),rs10757278和GG基因型(OR=1.978;95%CI:1.413-2.769;P<0.001);我们注意到,rs10757278的GG基因型与CHD之间的显着相互作用关联在吸烟类别中有所不同,高血压,CHD家族史,BMI。
GG基因型rs10757278可能是冠心病的危险因素。且9p21基因rs10757278区GG基因型与传统风险因子之间存在交互效应。
To
study the interaction effects of rs10757278 polymorphisms at 9p21 locus and traditional risk factors on coronary heart disease (CHD) in Xinjiang, China.
This case-control
study consecutively enrolled 310 unrelated consecutive CHD patients aged 18-70 years old. All
study participants were recruited between January and December 2017 from The Heart Center of The First Affiliated Hospital of Xinjiang Medical University. CHD patients were confirmed by coronary angiography (≥50% diameter stenosis in at least one of the major coronary arteries) according to the American Heart Association criteria for the confirmation of CHD. Healthy subjects were randomly selected from the occupational population, who received physical examination in our hospital and matched to cases on the basis of age (±3 years) and sex, those without medical history of cardiovascular diseases, and 536 subjects were selected as the control group after medical history inquiry, physical examination, cardiac ultrasound, electrocardiogram, and other blood biochemical examinations in the hospital. The occupational stress was evaluated by an effort-reward imbalance questionnaire. An epidemiological survey was conducted to collect clinical data. Chi-squared test, analysis of variance, and binary logistic regression analysis were adopted.
Both the case and the control groups showed significant difference in smoking, drinking, physical activity, hypertension, diabetes mellitus, family history of CHD, and body mass index (BMI) (all P < 0.05); prevalence of CHD was not related to occupational stress. There was no significant difference in occupational stress level between the 2 groups (P > 0.05); Differences in rs10757278 genotype between the case group and the control groups were statistically significant; binary logistic regression analysis was used to evaluate the risk factors of CHD. After adjustment for age and sex, significant increased risk effects for CHD were found to be associated with smoking [odds ratio (OR) = 2.311; 95% confidence interval (CI): 1.04-2.499; P < 0.001], physical exercise (OR = 1.365; 95% CI: 1.137-1.639; P < 0.001), hypertension (OR = 4.627; 95% CI: 2.165-10.764; P < 0.001), family history of CHD (OR = 4.103; 95% CI: 3.169-6.892; P < 0.001), BMI (OR = 2.484; 95% CI: 2.036-3.03; P < 0.001), and GG genotype at rs10757278 (OR = 1.978; 95% CI: 1.413-2.769; P < 0.001); We noted that a significant interaction association between GG genotype at rs10757278 and CHD differs across categories of smoking, hypertension, family history of CHD, and BMI.
GG genotype at rs10757278 may be a risk factor for CHD. And there are interaction effects between GG genotype of rs10757278 in region 9p21 gene and traditional risk factors.