背景:查加斯病与缺血性卒中之间的复杂关系尚不清楚。关于二级预防的证据有限,病因诊断,和中风相关的决定因素。这项研究旨在通过对比有和没有缺血性中风史的患者来辨别与查加斯病中风相关的因素。
方法:回顾性研究了来自两家巴西医院(一家Chagas中心和一家卒中诊所)的所有门诊Chagas病患者的数据。进行描述性分析以确定卒中相关因素。比较有和没有缺血性中风史的患者之间的变量。
结果:在678名受试者中,72人经历过中风。与中风的单变量关联包括男性,心力衰竭,先前或正在酗酒,心电图特征(非窦性心律,左束支,右束支传导阻滞,左前上束状传导阻滞,心房颤动),以及超声心动图显示左心室射血分数降低和节段异常。经过逻辑回归(多变量分析),充血性心力衰竭,右束支传导阻滞,左前上分区阻滞,和心房纤颤保持独立关联。
结论:在这项研究中,心脏受累成为与查加斯病卒中相关的主要因素。虽然动脉粥样硬化相关的危险因素普遍存在,它们对查加斯病中缺血性卒中的影响似乎有限.
BACKGROUND: The intricate relationship between Chagas disease and ischemic stroke remains unclear. Limited evidence exists concerning secondary prophylaxis, etiological diagnosis, and stroke-related determinants. This study aims to discern factors linked to stroke in Chagas disease by contrasting patients with and without a history of ischemic stroke.
METHODS: Retrospective data from all outpatient Chagas disease patients from two Brazilian hospitals - one Chagas center and one stroke clinic - were examined. Descriptive analyses were conducted to identify stroke-associated factors. Variables were compared between patients with and without ischemic stroke history.
RESULTS: Among 678 subjects, 72 had experienced stroke. Univariate associations with stroke included male gender, heart failure, prior or ongoing alcoholism, electrocardiographic features (non-sinus rhythm, left bundle branch, right bundle branch block, left anterosuperior fascicular block, atrial fibrillation), as well as echocardiographic findings indicative of reduced left ventricular ejection fraction and segmental abnormalities. After logistic regression (multivariate analysis), congestive heart failure, right bundle branch block, left anterosuperior divisional block, and atrial fibrillation retained independent associations.
CONCLUSIONS: In this study, cardiac involvement emerged as the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors were prevalent, their influence on ischemic stroke in Chagas disease appeared limited.