背景:宫颈癌(CC)是一种潜在的致命疾病,可能对女性健康造成严重后果。因为早期症状通常只出现在疾病的中晚期,临床诊断和治疗具有挑战性。中药(TCM)已被证明在缓解癌症临床症状方面具有独特的益处,降低手术后复发的风险,减少放疗后的毒副作用和药物耐药性。它还被证明可以改善患者的生活质量。由于其提高了抗肿瘤的有效性和生物安全性,它可以被认为是一种替代疗法。本研究探讨了中药如何通过信号转导引起CC细胞凋亡,包括活性成分和药用补品。旨在为CC的中医治疗提供可靠的临床依据和方案选择。
方法:以下搜索词在PubMed中使用,WebofScience,Embase,CNKI,万方,VIP,SinoMed,和其他科学数据库检索有关“宫颈癌”的相关文献,“\”凋亡,\"\"信号通路,\"\"中药,“\”草药单体,“\”草药成分,“\”草药提取物,\"和\"草药配方。\"
结果:已经证明,草药可以诱导子宫颈细胞凋亡,一种癌症,通过影响所涉及的信号通路。
结论:进行了全面的文献检索,2017年1月至2023年12月期间的148篇论文被确定有资格纳入.经过细致的筛选,消除和总结,泛化,和分析,发现中药可以调节多个细胞内信号通路及相关分子靶点,如STAT3、PI3K/AKT、Wnt/β-catenin,MAPK,NF-κB,p53,HIF-1α,Fas/FasL等等。观察到这种调节能力在宫颈癌细胞中诱导凋亡。中药抗宫颈癌作用机制的研究和新药靶点的筛选对今后该领域的研究具有重要意义。本研究结果将为中医药在宫颈癌诊治中的未来发展提供思路和参考。
BACKGROUND: Cervical cancer (CC) is a potentially lethal disorder that can have serious consequences for a woman\'s health. Because early symptoms are typically only present in the middle to late stages of the disease, clinical diagnosis and treatment can be challenging. Traditional Chinese medicine (TCM) has been shown to have unique benefits in terms of alleviating cancer clinical symptoms, lowering the risk of recurrence after surgery, and reducing toxic side effects and medication resistance after radiation therapy. It has also been shown to improve the quality of life for patients. Because of its improved anti-tumor effectiveness and biosafety, it could be considered an alternative therapy option. This study examines how TCM causes apoptosis in CC cells via signal transduction, including the active components and medicinal tonics. It also intends to provide a reliable clinical basis and protocol selection for the TCM therapy of CC.
METHODS: The following search terms were employed in PubMed, Web of Science, Embase, CNKI, Wanfang, VIP, SinoMed, and other scientific databases to retrieve pertinent literature on \"cervical cancer,\" \"apoptosis,\" \"signaling pathway,\" \"traditional Chinese medicine,\" \"herbal monomers,\" \"herbal components,\" \"herbal extracts,\" and \"herbal formulas.\"
RESULTS: It has been demonstrated that herbal medicines can induce apoptosis in cells of the cervix, a type of cancer, by influencing the signaling pathways involved.
CONCLUSIONS: A comprehensive literature search was conducted, and 148 papers from the period between January 2017 and December 2023 were identified as eligible for inclusion. After a meticulous process of screening, elimination and summary, generalization, and analysis, it was found that TCM can regulate multiple intracellular signaling pathways and related molecular targets, such as STAT3, PI3K/AKT, Wnt/β-catenin, MAPK, NF-κB, p53, HIF-1α, Fas/FasL and so forth. This regulatory capacity was observed to induce apoptosis in cervical cancer cells. The study of the mechanism of TCM against cervical cancer and the screening of new drug targets is of great significance for future research in this field. The results of this study will provide ideas and references for the future development of Chinese medicine in the diagnosis and treatment of cervical cancer.