PDF(Pubmed)
Abstract：
Primary malignant melanoma (MM) arising from the cervix is an exceedingly rare occurrence, and patients diagnosed with this condition often face a dismal clinical prognosis. Here, we present a case study of a postmenopausal woman presenting with vaginal bleeding and a conspicuous 5-centimeter black mass on the cervix. Based on the staging criteria established by the International Federation of Gynecology and Obstetrics, she was diagnosed with stage IIB primary cervical MM. The patient underwent neoadjuvant therapy prior to a radical hysterectomy and a bilateral salpingo-oophorectomy. Subsequently, she completed 18 cycles of pembrolizumab therapy, achieving clinical complete remission. Notably, at the 31-month follow-up, there were no signs of recurrence. This successful treatment outcome serves as a valuable clinical reference for the management of primary cervical MM.
摘要：
由子宫颈引起的原发性恶性黑色素瘤（MM）非常罕见，被诊断患有这种疾病的患者通常面临不良的临床预后。这里,我们提供了一个绝经后妇女的案例研究，该妇女表现为阴道出血和宫颈上明显的5厘米黑色肿块。根据国际妇产科联合会制定的分期标准，她被诊断为IIB期原发性宫颈MM。患者在根治性子宫切除术和双侧附件卵巢切除术前接受了新辅助治疗。随后，她完成了18个周期的pembrolizumab治疗，实现临床完全缓解。值得注意的是,在31个月的随访中，没有复发的迹象。这种成功的治疗结果为原发性宫颈MM的治疗提供了有价值的临床参考。
