这篇全面的综述通过研究组织蛋白酶B表达在口腔鳞状细胞癌(OSCC)发病机理中的作用,探讨了口腔鳞状细胞癌(OSCC)的复杂前景。OSCC,一种普遍且具有临床意义的口腔恶性肿瘤,构成了相当大的全球健康负担,有必要彻底探索其潜在的分子机制。组织蛋白酶B,一种溶酶体半胱氨酸蛋白酶,在OSCC中成为关键参与者,影响肿瘤的启动,入侵,和转移。回顾首先简要概述了OSCC,强调其流行病学和临床特征,然后探讨在此背景下研究组织蛋白酶B表达的意义。在手稿中,阐明了组织蛋白酶B的结构和功能,为理解其在OSCC中的异常表达提供了基础。临床研究揭示了与肿瘤分级和分期的相关性,连同预后意义,被仔细检查,提供对组织蛋白酶B的潜在诊断和预后效用的见解。组织蛋白酶B在OSCC中的生物学功能,包括其对肿瘤侵袭和细胞凋亡调节的影响,进行了全面的讨论。治疗意义部分探讨了靶向组织蛋白酶B作为一种潜在策略,强调未来研究需要克服相关挑战。在结论部分,审查综合了关键发现,描绘了对未来研究的影响,并强调了组织蛋白酶B对OSCC诊断和治疗的潜在影响,促进我们对这种复杂恶性肿瘤的理解,这与高死亡率相关并改善临床结局。
This comprehensive
review delves into the intricate landscape of oral squamous cell carcinoma (OSCC) by examining the role of cathepsin B expression in its pathogenesis. OSCC, a prevalent and clinically significant oral malignancy, poses a considerable global health burden, necessitating a thorough exploration of its underlying molecular mechanisms. Cathepsin B, a lysosomal cysteine protease, emerges as a critical player in OSCC, influencing tumour initiation, invasion, and metastasis. The
review begins with a brief overview of OSCC, emphasizing its epidemiological and clinical features, followed by exploring the significance of studying cathepsin B expression in this context. In the manuscript, the structure and function of cathepsin B are elucidated, providing a foundation for understanding its aberrant expression in OSCC. Clinical studies revealing correlations with tumour grade and stage, along with prognostic significance, are scrutinized, offering insights into the potential diagnostic and prognostic utility of cathepsin B. The biological functions of cathepsin B in OSCC, including its impact on tumour invasion and modulation of apoptosis, are comprehensively discussed. The Therapeutic Implications section explores targeting cathepsin B as a potential strategy, emphasizing the need for future research to overcome associated challenges. In the Conclusion section, the
review synthesizes key findings, delineates implications for future research, and highlights the potential impact of cathepsin B on OSCC diagnosis and treatment, contributing to the ongoing efforts to advance our understanding of this complex malignancy, which is associated with a high mortality rate and improve clinical outcomes.