Abstract：
Exercise has been shown repeatedly to improve cognitive functions. Many investigators have reported that peripheral signal molecules play an important role in regulating exercise-induced cognitive improvement. In this review we aimed to evaluate and clarify the literature to date that has focused on the relationship between Cathepsin B, cognitive functions, and exercise. We conducted a systematic review of the following databases from their inception until 10 April 2022: Pubmed, Web of Science, Scopus, Cochrane Library, Physiotherapy Evidence Database. The search strategy was comprised of (\"cathepsin b\") AND (exercise OR \"physical activity\") AND (cognit*). We followed three different quality appraisal tools to ensure the quality of the included studies. Eight studies assessing the effects of exercise on peripheral Cathepsin B levels and cognitive outcomes were included. Half of these studies indicated that exercise increased peripheral Cathepsin B levels and improved cognitive function. Further carefully designed studies focusing on the effects of exercise on peripheral Cathepsin B levels and cognitive performance are needed to better comprehend the underlying mechanisms of these relationships.
摘要：
运动已被反复证明可以改善认知功能。许多研究人员报道，外周信号分子在调节运动引起的认知改善中起重要作用。在这篇综述中，我们旨在评估和澄清迄今为止关注组织蛋白酶B之间关系的文献，认知功能，和锻炼。我们对以下数据库从成立到2022年4月10日进行了系统评价：Pubmed，WebofScience,Scopus,科克伦图书馆,物理治疗证据数据库。搜索策略包括（“组织蛋白酶b”）和（运动或“身体活动”）和（认知*）。我们遵循了三种不同的质量评估工具，以确保纳入研究的质量。包括八项评估运动对外周组织蛋白酶B水平和认知结果的影响的研究。这些研究中有一半表明，运动增加了外周组织蛋白酶B水平并改善了认知功能。需要进一步精心设计的研究，重点是运动对外周组织蛋白酶B水平和认知表现的影响，以更好地理解这些关系的潜在机制。
