目的:焦亡是一种新发现的程序性促炎细胞死亡形式。主要信号通路包括依赖于NLRP3炎性囊泡和其他活化半胱天冬酶-1的经典烧焦死亡通路和依赖于半胱天冬酶-4/5/11的非经典烧焦死亡通路。所有炎性胱天蛋白酶的底物是GSDMD;大量研究证实焦亡与某些感染性疾病有关,动脉粥样硬化疾病,代谢性疾病,和重要器官的无菌性炎症性疾病。近年来,已在眼部领域部分研究了焦度。所以,本文综述了最近的文献,旨在帮助读者了解细胞焦烧死亡的主要机制以及GSDMD介导的细胞焦烧死亡在视网膜血管炎症性疾病中的研究进展。
方法:详细综述了与视网膜血管系统的焦亡和炎性疾病相关的文献。检索到以下6个电子数据库:CNKI,万方,VIP,PubMed,科克伦图书馆,和Embase数据库,搜索期从数据库到2022年5月。主要搜索关键词包括\"焦度,\"\"GSDMD,\"\"视网膜血管炎性疾病,糖尿病视网膜病变,\"\"视网膜血管炎。“焦亡的发现,主要的分子机制,关键蛋白质,并对其在视网膜血管炎疾病中的发病机制和治疗前景进行了广泛的研究和总结。
结果:阐述和分析了gasderminD介导的焦亡的机制,尤其强调了它们在炎症性视网膜血管病变的发病机制和治疗中的关键作用和潜力。
结论:GasderminD介导的焦亡是一种经过充分研究的程序性促炎细胞死亡形式,对多种免疫和炎性疾病具有双向调节作用。文献揭示焦亡与视网膜血管炎症性疾病的发病机制密切相关,它可能是未来糖尿病视网膜病变和其他视网膜血管炎眼病的重要治疗靶点。
OBJECTIVE: Pyroptosis is a newly discovered form of programmed pro-inflammatory cell death. The main signaling pathways include the classical scorch death pathway that depends on NLRP3 inflammatory vesicles and other activation
caspase-1 and the non-classical scorch death pathway that depends on
caspase-4 /5/11. The substrate of all inflammatory caspases is GSDMD; a large number of studies have confirmed that pyroptosis is associated with certain infectious diseases, atherosclerotic diseases, metabolic diseases, and aseptic inflammatory diseases of important organs. In recent years, pyroptosis has been studied partially in the ocular field. So, this article reviews the recent literature intending to help readers understand the main mechanisms of cellular scorch death and the progress of GSDMD-mediated cellular scorch death in retinal vascular inflammatory diseases.
METHODS: A detailed
review of the literature related to pyroptosis and inflammatory diseases of the retinal vasculature is presented. The following 6 electronic databases were searched: CNKI, Wanfang, VIP, PubMed, The Cochrane Library, and Embase Databases, and the search period was from the database to May 2022. The main search keywords include \"Pyroptosis,\" \" GSDMD,\" \"Retinal Vascular Inflammatory Disease,\" \"Diabetic retinopathy,\" \"Retinal vasculitis.\" The discovery of pyroptosis, the main molecular mechanisms, key proteins, and their pathogenesis and therapeutic prospects in retinal vasculitis diseases are extensively studied and summarized.
RESULTS: The mechanisms of gasdermin D-mediated pyroptosis are elaborated and analyzed, with particular emphasis on their key role and potential in the pathogenesis and treatment of inflammatory retinal vascular lesions.
CONCLUSIONS: Gasdermin D-mediated pyroptosis is a well-studied form of programmed pro-inflammatory cell death, which has a bidirectional regulatory effect on a variety of immune and inflammatory diseases. The literature reveals that pyroptosis is closely related to the pathogenesis of retinal vascular inflammatory diseases, and it may be an important therapeutic target for diabetic retinopathy and other retinal vasculitis eye diseases in the future.