牙源性角化囊肿(OKC)是侵袭性囊肿,具有很高的复发潜力。单独使用手术摘除术治疗它们与高复发率相关;因此,额外或支持性治疗方法,比如外周截骨术,冷冻疗法,和化学解决方案,是有保证的。本综述的目的是评估现有的关于化学方法功效的文献,例如Carnoy\的解决方案(CS),防止OKC摘除后复发。在PubMed上进行了电子搜索,Scopus,和GoogleScholar数据库使用医学主题词“牙源性角化囊肿”“Carnoy解决方案”查找2010年1月至2022年12月发表的文章,\"\"治疗,\"和\"摘除。“选择了以英语发表的文章进行研究。PICOS标准(人群:组织病理学诊断为非综合征性OKC患者,至少随访6个月;干预和比较:摘除后进行辅助化学疗法和标准程序;结果:复发率;研究设计:回顾性和前瞻性研究,随机对照试验,以及涉及至少10例OKC)的病例系列。搜索中排除了涉及综合征(结节状基底细胞癌)病例的研究。17项研究符合纳入标准,其中大多数是回顾性研究,几个案例系列。OKC更常见于下颌骨,复发率为11%,在随访四年后摘除后接受CS治疗。在两项研究中使用了改良的Carnoy溶液(MC)。平均随访期为44个月。根据我们的发现,摘除后使用化学方法进行辅助治疗是治疗OKC的更有效和有益的方式。
Odontogenic keratocysts (OKC) are aggressive cysts with a high recurrence potential. Treating them with surgical enucleation procedures alone is associated with high recurrence rates; therefore, additional or supportive treatment approaches, such as peripheral osteotomy, cryotherapy, and chemical solutions, are warranted. The objective of the present
review was to evaluate the existing literature on the efficacy of chemical approaches, such as Carnoy\'s solution (CS), in preventing recurrence after the enucleation of OKC. An electronic search was conducted on PubMed, Scopus, and Google Scholar databases to find articles published from January 2010 to December 2022 by using the Medical Subject Headings (MeSH) terms \"Odontogenic Keratocyst\" \"Carnoy\'s Solution,\" \"Treatment,\" and \"Enucleation.\" Articles published in the English language were selected for the study. The PICOS criteria (population: patients with non-syndromic OKC with histopathological diagnosis and a minimum follow-up of six months; intervention and comparison: enucleation followed by adjunctive chemical therapy and standard procedure; outcome: recurrence rates; study design: retrospective and prospective studies, randomized controlled trials, and case series involving at least 10 cases of OKC) were employed. Studies involving syndromic (nevoid basal cell carcinoma) cases were excluded from the search. Seventeen studies fulfilled the inclusion criteria and the majority of them were retrospective studies, with a few case series. OKC was found more frequently in the mandible, with a recurrence rate of 11%, when treated with CS following enucleation after four years of follow-up. Modified Carnoy\'s solution (MC) was used in two studies. The mean follow-up period was 44 months. Based on our findings, adjuvant therapy using a chemical approach following enucleation is a more effective and beneficial modality for the treatment of OKC.