背景:2019年冠状病毒病(COVID-19)后持续症状的挑战,尤其是令人衰弱的心肺表现,需要进一步探索。我们的研究旨在评估重症COVID-19患者出院后一年的心肺并发症,将这些结果与非COVID组的结果进行对比。
方法:OneCoV2研究,一个潜在的,病例对照研究,在印度北部的三级护理教学医院进行。我们登记了43名受试者,平均年龄25.57±7.94岁(COVID组)和27.30±8.17岁(非COVID组)。综合检查包括肺功能检查,心脏功能试验,6分钟步行测试,和实验室调查。
结果:肺功能[强制肺活量(FVC)(p=0.037),用力呼气流量(FEF)25-75%(p=0.013)],和心功能[左心室射血分数(LVEF)(p=0.032),心率(HR)(p=0.047)],以及两组之间的六分钟步行测试结果。在COVID组中,Pearson相关显示FVC与C反应蛋白(CRP)呈负相关[r=-0.488,p=0.007],六分钟步行试验[r=0.431,p=0.003]与HR[r=0.503,p=0.013]呈正相关。
结论:我们的数据表明,即使在出院1年后,COVID患者的肺部异常也很普遍。心脏生物标志物也显示出倾向于COVID组。虽然我们发现涉及一些参数如FVC的显著相关性,CRP,HR,六分钟步行测试的结果,在我们的研究中,我们没有发现与其他测试参数有显著相关性.
BACKGROUND: The evolving challenge of persistent symptoms post-Coronavirus disease-2019 (COVID-19), particularly debilitating cardio-pulmonary manifestations, necessitates further exploration. Our study aimed to assess the cardio-pulmonary complications in patients a year after hospital discharge from severe COVID-19, contrasting these with findings from a non-COVID group.
METHODS: The OneCoV2 study, a prospective,
case-control study, was conducted at a tertiary care teaching hospital in northern India. We enrolled 43 subjects, with a mean age of 25.57 ± 7.94 years (COVID group) and 27.30 ± 8.17 years (non-COVID group). Comprehensive tests included pulmonary function tests, cardiac function tests, 6-min walk tests, and laboratory investigations.
RESULTS: Significant differences were found in the pulmonary function [forced vital capacity (FVC) (p = 0.037), forced expiratory flow (FEF) 25-75 % (p = 0.013)], and cardiac function [left ventricular ejection fraction (LVEF) (p = 0.032), heart rate (HR) (p = 0.047)], along with the six-minute walk test results between the two groups. In the COVID group, Pearson\'s correlation showed a negative correlation between FVC and C-reactive protein (CRP) [r = -0.488, p = 0.007] and a positive correlation between the six-minute walk test [r = 0.431, p = 0.003] and HR [r = 0.503, p = 0.013].
CONCLUSIONS: Our data suggest that pulmonary abnormalities are prevalent in COVID patients even after 1-year of hospital discharge. Cardiac biomarkers also show an inclination towards the COVID group. While we found significant correlations involving some parameters like FVC, CRP, HR, and results from the six-minute walk test, we did not find any significant correlations with the other tested parameters in our study.