背景:原发性粘液表皮样癌(MEC)是一种常见的涎腺恶性肿瘤,但在胰腺中非常罕见。迄今为止,文献中仅报道了10例。因为胰腺的MEC非常罕见,关于它的诊断的信息很少,治疗,和转移。在这里,我们介绍了第11例病例,并回顾了相关文献。
方法:一名65岁的女性在腹部磁共振成像中表现为胰腺体肿块和肝脏多发肿块。该患者最初接受了EUS引导的细针抽吸术,并被诊断为腺癌。辅助化疗后,切除胰体和胰尾,组织是病理上的,组织学上,和免疫化学检查。分析了特定菌株和基因重排。
方法:粘膜表皮样胰腺癌。
方法:经过4个月的辅助化疗,进行腹腔镜手术。
结果:患者在提交本论文之前一直存活。
结论:我们介绍了一例65岁女性的粘液表皮样胰腺癌。病理检查显示肿瘤实质由3种细胞类型组成。主要有表皮样细胞,介于基底细胞和表皮样细胞之间的中间细胞,和不同比例的粘液产生细胞。免疫组织化学染色显示有不同类型的细胞具有独特的形态学特征。总之,胰腺的原发性MECs罕见且预后不良。很少有关于诊断的研究,治疗,和MECs的转移;因此,需要进一步的研究来检测它们。
BACKGROUND: Primary mucoepidermoid carcinoma (MEC) is a common malignant neoplasm of the salivary glands, but is very rare in the pancreas. To date, only 10 cases have been reported in the literature. Because MEC of the pancreas is very rare, there is little information about its diagnosis, treatment, and metastasis. Herein, we present the eleventh
case and review the relevant literature.
METHODS: A 65-year-old woman presented with a mass in the body of the pancreas and multiple masses in the liver on abdominal magnetic resonance imaging. The patient initially underwent EUS-guided fine-needle aspiration and was diagnosed with adenocarcinoma. After adjuvant chemotherapy, resection of the pancreatic body and tail was performed, and the tissues were pathologically, histologically, and immunochemically examined. Specific strains and gene rearrangements were analyzed.
METHODS: Mucoepidermoid pancreatic cancer.
METHODS: After a 4-month course of adjuvant chemotherapy, laparoscopic surgery was performed.
RESULTS: The patient is alive until the submission of this paper.
CONCLUSIONS: We presented a
case of mucoepidermoid pancreatic cancer in a 65-year-old woman. Pathological examination revealed that the tumor parenchyma consisted of 3 cell types. There are mainly epidermoid cells, intermediate cells between the basal and epidermoid cells, and mucus-producing cells in varying proportions. Immunohistochemical staining showed that there were different types of cells with unique morphological characteristics. In summary, primary MECs of the pancreas are rare and have poor prognosis. Few studies have been conducted on the diagnosis, treatment, and metastasis of MECs; therefore, further studies are needed to detect them.