目的:最近的研究发现,大脑淀粉样β(Aβ)积累增加与几种异常的睡眠-觉醒模式有关,包括临床前阿尔茨海默病(AD)的潜伏期缩短和碎片化增加。关于睡眠和tau之间的关系知之甚少。这项研究的目的是了解tau和Aβ与临床正常老年人睡眠早期迹象和夜间行为变化的关系。具体来说,我们已经解决了基于信息的主观睡眠报告如何与区域[18F]flortaucipir和[18F]florbetapir摄取相关联的问题。
方法:35名受试者的影像学和行为数据来自阿尔茨海默病神经影像学倡议。神经精神量表睡眠(NPI-sleep)问卷用于评估睡眠和夜间行为变化。区域tau-正电子发射断层扫描(PET)(内嗅,脑干)和Aβ-PET(后扣带回,precuneus,计算内侧眶额)摄取值。使用一系列线性回归分析来确定睡眠症状的组合,从而建立预测每种病理的最佳模型。
结果:基于信息的异常夜间行为报告(NPI问题k3,k5和k8)与内嗅tau和Aβ(所有区域)积累的增加显着相关。有趣的是,基于信息的无异常夜间活动的睡眠不足报告(NPI问题k1,k2和k6)与内嗅tau负荷呈负相关.
结论:异常夜间行为的检测(徘徊,起搏,家庭成员的其他不适当活动)表明两种AD病理的早期迹象,并可能鼓励受影响的个体寻求医疗保健提供者的帮助以进行详细的认知/神经行为评估。
OBJECTIVE: Recent studies have found associations of increased brain amyloid beta (Aβ) accumulation and several abnormal sleep-wake patterns, including shorter latency and increased fragmentation in preclinical Alzheimer\'s disease (AD). There is little known about the relationship between sleep and tau. The objective of this study was to understand the associations of both tau and Aβ with early signs of sleep and night-time behavior changes in clinically normal elderly adults. Specifically, we have addressed the question of how informant-based subjective sleep
reports are linked to regional [18F]flortaucipir and [18F]florbetapir uptake.
METHODS: Imaging and behavioral data from 35 subjects were obtained from the Alzheimer\'s Disease Neuroimaging Initiative. The Neuropsychiatric Inventory Sleep (NPI-sleep) Questionnaire was used to assess the sleep and night-time behavior changes. Regional tau-positron emission tomography (PET) (entorhinal, brainstem) and Aβ-PET (posterior cingulate, precuneus, medial orbitofrontal) uptake values were calculated. A series of linear regression analyses were used to determine the combination of sleep symptoms that built the best models to predict each pathology.
RESULTS: Informant-based
reports of abnormal night-time behavior (NPI questions k3, k5, and k8) were significantly associated with increased entorhinal tau and Aβ (all regions) accumulation. Interestingly, informant-based
reports of sleep deficiencies without abnormal nigh-time activity (NPI questions k1, k2, and k6) were negatively associated with entorhinal tau burden.
CONCLUSIONS: Detection of abnormal night-time behaviors (wandering, pacing, other inappropriate activities) by family members indicates early signs of both AD pathologies and may encourage the affected individuals to seek help by health care providers for detailed cognitive/neurobehavioral assessments.