通过客观工具调查酒精滥用的必要性在世界范围内被接受。在目前可用的慢性酒精滥用的生物标志物中,碳水化合物缺乏转铁蛋白(CDT)是最常用的指标之一,主要是因为其特异性高。然而,一些CDT分析和解释方面仍在讨论中,许多研究论文和评论都见证了这一点。本文对2007年至2017年(包括在内)期间出现的CDT文献进行了批判性回顾。本文分为以下几个部分:(1)绪论,(2)预分析方面(3)分析方面(4)诊断方面(5)结束语。多达139篇论文出现在国际文献中,并由搜索引擎PubMed检索,引用了WebofScience和Scopus。
The need for investigating alcohol abuse by means of objective tools is worldwide accepted. Among the currently available biomarkers of chronic alcohol abuse, carbohydrate-deficient transferrin (CDT) is one of the most used indicator, mainly because of its high specificity. However, some CDT analytical and interpretation aspects are still under discussion, as witnessed by numerous research papers and reviews. The present article presents a critical
review of the literature on CDT appeared in the period from 2007 to 2017 (included). The article is organized in the following sections: (1) introduction, (2) pre-analytical aspects (3) analytical aspects (4) diagnostic aspects (5) concluding remarks. As many as 139 papers appeared in the international literature and retrieved by the search engines PubMed, Web of Science and Scopus are quoted.