背景:迄今为止,维生素D摄入与消化系统癌症发生的关系仍然引起研究者的争论。这项研究旨在调查维生素D摄入与消化系统癌症(食道癌,胃,肝,胰腺,和结直肠癌)通过双样本孟德尔随机化(MR)分析,使用从IEUOpenGWAS数据库派生的数据集。
方法:本研究基于维生素D和消化系统癌症的全基因组关联研究(GWAS)。样本量范围从218,792到496,946个欧洲血统个体。该研究首先使用逆方差加权(IVW)调查了维生素D与每种消化系统癌症之间的因果关系,加权中位数,和MR-Egger回归,然后使用荟萃分析总结不同癌症的IVW结果。我们还进行了额外的敏感性测试,以评估结果的有效性。
结果:在这项研究中,我们筛选出117个SNP作为25(OH)D的潜在工具变量,并确定101个固定SNP作为消化系统癌症的工具变量.IVW结果未能揭示遗传易感维生素D水平与消化系统癌症风险之间的任何因果关系(食管癌p=0.400,OR=1.397,95%CI0.642-3.040;胃癌p=0.796,OR=0.939,95%CI0.585-1.510;肝癌p=0.347,OR=1.445,95%CI0.671-3.109;胰腺癌p=0.6618,0.95OR=0.5127合并OR(比值比)为0.918(95%CI0.770-1.097,p=0.348)。
结论:维生素D与消化系统癌症的发生之间没有因果关系。消化系统癌症的风险不能仅仅通过增加维生素D的摄入量来减轻。
BACKGROUND: Hitherto, the association of vitamin D intake and digestive system cancers occurrence still causes disputation among the researchers. This
study aimed to investigate the genetic relation between vitamin D ingestion and digestive system cancers (which are esophageal, gastric, hepatic, pancreatic, and colorectal cancers) by a two-sample Mendelian randomization (MR) analysis, using datasets derived from IEU OpenGWAS database.
METHODS: This
study is based on a genome-wide association
study (GWAS) for vitamin D and digestive system cancers, with a sample amount ranging from 218,792 to 496,946 European ancestry individuals. The
study first investigated the causal relationship between vitamin D and each digestive system cancers using inverse-variance weighting (IVW), weighted medians, and MR-Egger regression and then used meta-analysis to summarize the IVW results for the different cancers. We also performed additional sensitivity tests to assess the validity of the results.
RESULTS: In this
study, we screened out 117 SNPs as potential instrumental variables for 25(OH)D and identified 101 fixed SNPs as instrumental variables for digestive system cancers. The results of the IVW failed to reveal any causal relationship between the genetically predisposed vitamin D level and the risk of digestive system cancers (esophageal cancer p = 0.400, OR = 1.397, 95% CI 0.642-3.040; gastric cancer p = 0.796, OR = 0.939, 95% CI 0.585-1.510; hepatic cancer p = 0.347, OR = 1.445, 95% CI 0.671-3.109; pancreatic cancer p = 0.905, OR = 0.969, 95% CI 0.581-1.618; colorectal cancer p = 0.127, OR = 0.0.841, 95% CI 0.673-1.051). The pooled ORs (odds ratio) are 0.918 (95% CI 0.770-1.097, p = 0.348).
CONCLUSIONS: There is no causal relationship between vitamin D and the occurrence of digestive system cancers. The risk of digestive system cancers cannot be alleviated by merely increasing vitamin D intake.