Cancer du rein

癌症
  • 文章类型: Journal Article
    背景:在70岁及以上的人群中,局限性肾细胞癌(RCC)的发病率呈上升趋势。虽然治疗的黄金标准仍然是手术切除,一些患有合并症的老年和体弱患者不符合此程序的条件。在某些情况下,经皮热消融,比如冷冻疗法,微波和射频,提供侵入性较小的选择。这种治疗有时需要全身麻醉,但大多数程序可以使用轻度或深度清醒镇静进行。这种方法优选推荐用于位于距肾门和/或输尿管一定距离处的小cT1a肿瘤。主动监测仍然是小的低级别RCC的替代方案,尽管它可能会引起某些患者的焦虑。最近的研究强调了立体定向消融体放射治疗(SABR)作为一种非侵入性,耐受性良好,对肾脏小肿瘤的有效治疗。这篇叙述性综述旨在探讨SABR在局部RCC中的最新进展,包括适当的患者选择,治疗方式和管理,以及疗效和耐受性评估。
    方法:我们使用术语[肾癌]进行了文献综述,[肾细胞癌],[立体定向放射治疗],[SBRT],和[SABR]在Medline,PubMed,和Embase数据库,重点关注英文发表的前瞻性和相关回顾性研究。
    结果:研究报告SABR的局部控制率从70%到100%不等,强调其治疗RCC的疗效。在SABR后的几年中,肾小球滤过率(GFR)的下降约为-5至-17mL/min。常见的毒性很少见,主要是CTCAE1级,包括疲劳,恶心,胸部或背部疼痛,腹泻,或胃炎。
    结论:立体定向消融体放疗(SABR)可被认为是局部RCC患者的可行选择,这些患者不适合手术,局部控制率高,安全性好。.应该在多学科会议上讨论这种方法,并等待正在进行的临床试验的结果。
    BACKGROUND: The incidence of localized renal cell carcinoma (RCC) is on the rise among individuals aged 70 and older. While the gold standard for treatment remains surgical resection, some elderly and frail patients with comorbidities are not eligible for this procedure. In selected cases, percutaneous thermal ablation, such as cryotherapy, microwave and radiofrequency, offers less invasive options. General anesthesia is sometimes necessary for such treatments, but most of the procedures can be conducted using mild or deep conscious sedation. This approach is preferably recommended for small cT1a tumors situated at a distance from the renal hilum and/or ureter. Active surveillance remains an alternative in the case of small low grade RCC although it may induce anxiety in certain patients. Recent research has highlighted the potentials of stereotactic ablative body radiotherapy (SABR) as a noninvasive, well-tolerated, and effective treatment for small renal tumors. This narrative review aims to explore recent advances in SABR for localized RCC, including appropriate patient selection, treatment modalities and administration, as well as efficacy and tolerance assessment.
    METHODS: We conducted a literature review using the terms [kidney cancer], [renal cell carcinoma], [stereotactic radiotherapy], [SBRT], and [SABR] in the Medline, PubMed, and Embase databases, focusing on prospective and relevant retrospective studies published in English.
    RESULTS: Studies report local control rates ranging from 70% to 100% with SABR, highlighting its efficacy in treating RCC. The decline in glomerular filtration rate (GFR) is approximately -5 to -17mL/min over the years following SABR. Common toxicities are rare, primarily CTCAE grade 1, include fatigue, nausea, chest or back pain, diarrhea, or gastritis.
    CONCLUSIONS: Stereotactic ablative body radiotherapy (SABR) may be considered as a viable option for patients with localized RCC who are not suitable candidates for surgery with a high local control rate and a favorable safety profile. This approach should be discussed in a multidisciplinary meeting and results from ongoing clinical trials are awaited.
    METHODS:
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  • 文章类型: Journal Article
    背景:机器人辅助手术在泌尿外科中越来越频繁。除了它在癌症前列腺切除术中的地位,它还涉及部分肾切除术(NP),在肾脏肿瘤的治疗中。这篇综述的目的是比较机器人辅助方法与腹腔镜或开放方法在部分肾切除术中的功能或肿瘤结局以及围手术期和术后并发症。
    方法:在PubMed上对2009年发表的文献进行了系统综述。在NP领域使用了比较机器人辅助手术与腹腔镜或开放手术的临床研究或荟萃分析。
    结果:这篇文献综述中提供的临床数据主要基于比较研究的荟萃分析。机器人辅助(NPAR)手术的患者术后并发症明显少于开腹手术(RR0.61;P=0.0002)或腹腔镜手术(RR0.84;P=0.007)。正边距,在相同的病理阶段,与开腹手术相当,似乎低于腹腔镜手术(RR0.53;P<0.001)。NP之后,3种途径间的术后肾小球滤过率(GFR)变化似乎相同.与NPL相比,NPAR的热缺血时间明显较短。最后,与开放手术相比,NPAR手术患者的估计失血量和住院时间较轻.
    结论:机器人辅助手术提供了相同的肿瘤学结果(短期和中期),并且似乎可以改善功能结局和发病率。然而,这些发现需要仔细分析,由于所提出和纳入荟萃分析的研究的证据水平较低,缺乏随机临床研究。
    BACKGROUND: Robot-assisted surgery is practiced more and more frequently in urology. Besides its place in prostatectomy for cancer, it also concerns partial nephrectomy (NP), in the treatment of renal tumors. The objective of this review is to compare the robot-assisted approach with laparoscopic or open approaches in partial nephrectomy in terms of functional or oncological outcomes and per- and postoperative complications.
    METHODS: A systematic review of the literature published from 2009 was carried out on PubMed. Clinical studies or meta-analyzes comparing robot-assisted surgery versus laparoscopic or open surgery in the NP domain were used.
    RESULTS: The clinical data presented in this review of the literature are based mainly on meta-analyzes of comparative studies. Patients operated with robotic assistance (NPAR) had significantly fewer postoperative complications than patients operated by open (RR 0.61; P=0.0002) or laparoscopic surgery (RR 0.84; P=0.007). Positive margins, at equivalent pathological stages, are comparable to the open and appear to be lower than the laparoscopic surgery (RR 0.53; P<0.001). After NP, the change in postoperative glomerular filtration rate (GFR) appears to be identical between the 3 pathways. Hot ischemia time is significantly shorter for NPAR compared to NPL. Finally, the estimated blood loss and length of stay are less severe in patients operated by NPAR compared to those operated by open surgery.
    CONCLUSIONS: Robot-assisted surgery offers the same oncological results (in the short and medium term) and appears to improve functional outcomes and morbidity. However, these findings need to be carefully analyzed, due to the low level of evidence from the studies presented and included in the meta-analyzes, and the lack of randomized clinical studies.
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  • 文章类型: English Abstract
    OBJECTIVE: To focus on indications and results of ablative treatments (cyoablation, radiofrequency) for small renal masses, a bibliographic research was conducted in MedLine database using terms of \"ablative treatment\", \"cryotherapy\", \"radiofrequency\", \"kidney cancer\", \"renal cell carcinoma\". Sixty-four articles were selected.
    RESULTS: Carcinologic outcomes seem to be better with cryoablation than with radiofrequency. Available results have to be balanced according to surgical approach, teams\' experience and duration of follow-up. Tumour\'s size and central localization are the main factors of failure. The size of 3cm is the most generally validated. Hospital stay and complications seem to be better with ablative therapies than with surgical approach, especially with percutaneous approach. The renal function preservation appears to be better with ablative therapies. It could be an interesting alternative to partial nephrectomy for small masses, in particular for fragile patients or in particular indications (multifocal tumors, in case of solitary kidney or transplanted kidney). The indications in elderly people must be proposed with care after the comorbidities have been evaluated.
    CONCLUSIONS: Indications of ablative treatment for small renal masses improve, but the gold standard treatment remains partial nephrectomy and indications must be individually discussed. Other ablative treatments are under-development, needing further studies.
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  • 文章类型: Case Reports
    在部分肾切除术中使用Hem-o-lok(®)夹子进行实质闭合的滑动夹技术主要用于腹腔镜手术,机器人,有时开放手术。我们在这里介绍了开放性肾部分切除术后夹子大量迁移的情况。我们讨论了这些剪辑的成像特征:在普通X射线上不可见,计算机断层扫描的低密度,在回顾以前发表的案例之前。
    The sliding-clip renorraphy technique using Hem-o-lok(®) clips for parenchymal closure in partial nephrectomy is largely used in laparoscopic, robotic and sometimes open surgery. We present here a case of massive migration of the clips after open partial nephrectomy. We discuss the imaging characteristics of those clips: not visible on plain X-ray, low density on computed tomography, before reviewing previously published cases.
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