■已经推测了微量元素与鼻咽癌(NPC)之间的关联,但尚未彻底检查。
■本研究共登记了广东省三家市级医院的225例新诊断的鼻咽癌患者和225例按性别和年龄相匹配的健康对照者,2011年至2015年中国南方。通过问卷调查收集有关人口统计学特征和其他可能混杂的生活方式因素的信息。采用电感耦合等离子体质谱(ICP-MS)和酶联免疫吸附试验(ELISA)测定血清标本中8种微量元素和EB病毒(EBV)抗体水平,分别。通过单元素和多元素模型,应用限制性三次样条和条件逻辑回归评估微量元素与NPC风险之间的关系。
■血清铬(Cr)水平,钴(Co),镍(Ni),砷(As),锶(Sr)和钼(Mo)与NPC风险无关。在单元素和多元素模型中,锰(Mn)和镉(Cd)与NPC风险呈正相关,与Mn的参考类别3.90(95%CI,1.27至7.34)和Cd的2.30(95%CI,1.26至3.38)相比,OR最高。受限三次样条表明,Mn和NPC风险呈线性增加趋势,而Cd则存在J型相关性。
■血清Cd和Mn水平与NPC风险呈正相关。未来应考虑对两种微量元素与NPC之间关联的前瞻性研究。
UNASSIGNED: Associations between trace elements and nasopharyngeal carcinoma (NPC) have been speculated but not thoroughly examined.
UNASSIGNED: This study registered a total of 225 newly diagnosed patients with NPC and 225 healthy controls matched by sex and age from three municipal hospitals in Guangdong Province, southern China between 2011 and 2015. Information was collected by questionnaire on the demographic characteristics and other possibly confounding lifestyle factors. Eight trace elements and the level of Epstein-Barr virus (EBV) antibody were measured in casual (spot) serum specimens by inductively coupled plasma-mass spectrometry (ICP-MS) and enzyme-linked immunosorbent assay (ELISA), respectively. Restricted cubic splines and conditional logistic regression were applied to assess the relationship between trace elements and NPC risk through single-and multiple-elements models.
UNASSIGNED: Serum levels of chromium (Cr), cobalt (Co), nickel (Ni), arsenic (As), strontium (Sr) and molybdenum (Mo) were not associated with NPC risk. Manganese (Mn) and cadmium (Cd) were positively associated with NPC risk in both single-and multiple-element models, with ORs of the highest tertile compared with the reference categories 3.90 (95% CI, 1.27 to 7.34) for Mn and 2.30 (95% CI, 1.26 to 3.38) for Cd. Restricted cubic splines showed that there was a linear increasing trend between Mn and NPC risk, while for Cd there was a J-type correlation.
UNASSIGNED: Serum levels of Cd and Mn was positively related with NPC risk. Prospective researches on the associations of the two trace elements with NPC ought to be taken into account within the future.