CF

CF
  • 文章类型: Journal Article
    有两种主要的补充喂养(CF)方法:传统的勺子喂养(TSF)和婴儿主导的断奶(BLW)。许多父母和医疗保健专业人员担心与BLW相关的窒息风险。由于窒息是婴儿死亡的主要原因之一,本研究旨在了解护理人员采用CF方法对婴儿窒息风险的影响。进行了系统评价。搜索是通过PubMed进行的,Scopus,和WebofScience数据库。我们纳入了2010年1月至2023年11月发表的随机对照试验或观察性研究,明确了干预措施的定义,并直接评估了窒息的风险。选择程序后,纳入了最初确定的165项研究中的7项。没有研究报告BLW后婴儿窒息风险的统计学差异,以婴儿为主导的固体介绍(BLISS),和TSF。在五项研究中,虽然没有统计学意义,TSF组的婴儿窒息发作次数多于BLW或BLISS组.窒息的风险似乎与CF方法无关。相反,这可能与婴儿对每个纹理的熟悉程度以及父母对如何最大程度地减少窒息风险的理解有关。在所有纳入的研究中可能存在召回偏差。关于如何修改食物以使其更安全的建议需要更清晰,并向所有父母加强。
    There are two main complementary feeding (CF) approaches: traditional spoon-feeding (TSF) and baby-led weaning (BLW). Many parents and healthcare professionals have concerns about the risk of choking associated with BLW. Since asphyxia is one of infants\' main causes of death, this study aims to understand the influence of the CF approach adopted by caregivers on infants\' risk of choking. A systematic review was performed. The search was conducted through PubMed, Scopus, and Web of Science databases. We included randomized controlled trials or observational studies published between January 2010 and November 2023, with a clear definition of the intervention and directly assessing the risk of choking. After the selection procedure, 7 of the 165 studies initially identified were included. No study reported statistically significant differences in the risk of choking between babies following BLW, baby-led introduction to solids (BLISS), and TSF. In five studies, although not statistically significant, infants in the TSF group had more choking episodes than those in the BLW or BLISS groups. The risk of choking does not seem to be associated with the CF approach. Instead, it may be related to the familiarity of the baby with each texture and the parent\'s understanding of the information about how to minimize the risk of choking. Recall bias may be present in all included studies. Advice on how to modify foods to make them safer needs to be clearer and reinforced to all parents.
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  • 文章类型: Systematic Review
    本系统综述总结了囊性纤维化(CF)对男性和女性性健康和生殖健康(SRH)的影响,涵盖青春期发育,荷尔蒙功能,计划生育,和生育能力。收录的文章介绍了历史CF诊断标准,临床前或临床数据(回顾性队列或开放标签试验),虽然被排除的文章缺乏全文可用性,明确的方法论,或CF和非CF患者之间的比较。CFTR突变的基因型差异影响症状严重程度。患有CF的男性经历了青春期延迟,性腺功能减退,阻塞性无精子症导致的不孕症,和精液参数问题。女性CF患者生育能力下降,可能与离子平衡破坏和卵巢囊性疾病有关。辅助生殖技术解决了生育问题,但是成功取决于疾病的严重程度和基因型。CFTR调节剂有助于肺功能和性健康,但需要进一步评估生育益处。
    This systematic review summarizes the impact of cystic fibrosis (CF) on sexual and reproductive health (SRH) in males and females, covering pubertal development, hormonal function, family planning, and fertility. Included articles featured historical CF diagnostic criteria, preclinical or clinical data (retrospective cohorts or open label trials), while excluded articles lacked full text availability, explicit methodology, or comparisons between CF and non-CF patients. Genotype differences in CFTR mutations influenced symptom severity. Males with CF experienced delayed puberty, hypogonadism, infertility from obstructive azoospermia, and semen parameter issues. Female CF patients showed decreased fertility, possibly linked to disrupted ionic balance and ovarian cystic disease. Assistive reproductive technologies addressed fertility issues, but success varied based on disease severity and genotype. CFTR modulators aided pulmonary function and sexual health but require further assessment for fertility benefits.
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  • 文章类型: Journal Article
    高等教育机构(HEI)或大学,作为从事教育的组织,研究和社区服务,在促进可持续发展中发挥重要作用。因此,它们越来越多地与计算碳足迹(CF)的倡议联系在一起,这是从温室气体(GHG)排放的角度评估可持续性的工具。本研究的目的是通过分析不同的关键要素,对学术机构的CF评估现状进行系统的回顾,比如时间段,方法和实践,计算工具,排放源,排放因素和减排计划。审查协议考虑了直到2021年3月发布的文章。在审查的文章中,35的目的是专门计算HEI的CF,而其余的文章包括审查,特定活动的CF评估或温室气体减排文章。当比较归一化CF的结果时,已经确定了明显的差异(平均2.67tCO2e/学生,范围从0.06到10.94)或碳抵消百分比,仅在14%的研究中考虑,范围从0.09%到18%。其主要原因是在时间度量方面缺乏标准化(年,学期),功能单元(学生,雇员,区域)和数据收集边界(范围1、2、3),排放源和排放因子,主要用于范围3(水的消耗和处理,废物处理,office,ICT和实验室耗材,通勤和旅行,建筑材料,食堂,等。),以及是否包含碳抵消项目的影响以抵消CF(项目目标和吸收来源和因素)。然而,尽管存在差异,随着时间的推移,一个减少是显而易见的。因此,HEI中的CF需要进一步改进和解决许多挑战,包括代表性排放源的定义,建立一个强大的排放因子数据库,并开发涵盖这类组织所有需求的工具/方法。
    Higher Education Institutions (HEI) or universities, as organisations engaged in education, research and community services, play an important role in promoting sustainable development. Therefore, they are increasingly linked to the initiative of calculating their carbon footprint (CF), which is a tool to assess sustainability from the perspective of greenhouse gas (GHG) emissions. The aim of this study is to carry out a systematic review of the current situation of CF assessment in academic institutions by analysing different key elements, such as the time period, methodologies and practises, calculation tools, emission sources, emission factors and reduction plans. The review protocol considered articles published until March 2021. Of the articles reviewed, 35 are aimed specifically at calculating the CF of HEI, while the remaining articles consist of review, activity-specific CF assessment or GHG emission reduction articles. Clear differences have been identified when results are compared for the normalised CF (average of 2.67 t CO2e/student, ranging from 0.06 to 10.94) or the percentage of carbon offsetting, only considered in 14% of the studies and ranging from 0.09 to 18%. The main reason for this is the lack of standardisation as regards the time metric (year, semester), functional unit (student, employee, area) and data collection boundary (scope 1, 2, 3), the emissions sources and emission factors, mainly for scope 3 (water consumption and treatment, waste treatment, office, ICT and laboratory consumables, commuting and travel, construction materials, canteens, etc.), and the inclusion or not of the effect of carbon offset projects to offset the CF (aim of the project and absorption sources and factors). However, despite the differences, a reduction over time is clearly observed. Therefore, CF in HEI requires further improvements and solutions to a number of challenges, including the definition of representative emission sources, the creation of a robust emission factor database and the development of tools/methodologies that cover all the needs of this type of organisation.
    UNASSIGNED:
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  • 文章类型: Journal Article
    背景:整个南亚(SA)儿童营养欠佳仍然是一个问题。适当的补充喂养方法(CFP)可以大大降低这种风险。CF研究的系统评价(SR)的主要目的是评估时机,饮食多样性,孟加拉国2岁以下儿童的用餐频率及影响因素。
    方法:搜索包括2000年1月至2016年6月在MEDLINE上发表的英语研究,EMBASE,全球卫生,WebofScience,OVID产妇和婴儿护理,BanglaJOL,科克伦图书馆,CINAHL,POPLINE和WHO全球卫生图书馆。资格标准:关于南亚0-2岁儿童和/或其家庭补充喂养做法是否充分的主要研究。我们排除了干预性论文和专门针对母乳喂养的论文。根据纳入标准,总共筛选了45712个标题和摘要,其中860份收到了两名审稿人的独立全文审稿。确定了36篇与孟加拉国有关的论文。使用“EPPI-证据中心权重框架”客观评估每个研究在回答评论问题时的价值。根据世卫组织婴幼儿喂养指南(IYCF)CF的引入被评估为接受固体的6-8个月婴儿的比例,半固体或软质食品。搜索词为:\"children\",“喂养”和“亚洲人”及其衍生物。两名研究人员进行了研究选择,数据提取和质量评价。
    结果:三个队列,包括30项横断面研究和3项混合方法研究。尽管采用了世卫组织IYCF准则,在许多研究中发现了次优的CF实践。CF实践的及时启动范围为24%至83%。实现的最低饮食多样性范围为25%至44%,最低进餐频率为33%至81%。影响因素包括母亲教育,对CF实践和社会经济变量知之甚少。
    结论:这是评估孟加拉国CF实践的第一个系统综述。尽管通过了世卫组织IYCF准则,孟加拉国各地的社区仍然存在不足的CFP。
    背景:PROSPERO注册号:CRD42014014025。
    BACKGROUND: Sub-optimal nutrition among children remains a problem across South Asia (SA). Appropriate complementary feeding practices (CFP) can greatly reduce this risk. The primary objective of this systematic review (SR) of CF studies was to assess timing, dietary diversity, meal frequency and influencing factors in children under two in Bangladesh.
    METHODS: Searches included English-language research published between January 2000 and June 2016 within MEDLINE, EMBASE, Global Health, Web of Science, OVID Maternity & Infant Care, BanglaJOL, Cochrane Library, CINAHL, POPLINE and WHO Global Health Library. Eligibility criteria: primary research concerning the adequacy of complementary feeding practices in South Asian children aged 0-2 years and/or their families. We excluded interventional papers and those focusing exclusively on breast-feeding. In total 45,712 titles and abstracts were screened against inclusion criteria, 860 of which received independent full text review by two reviewers. 36 papers relevant to Bangladesh were identified. The \'EPPI-Centre Weight of Evidence Framework\' was used to objectively assess each study\'s value in answering the review question. As per WHO Infant and Young Children Feeding Guidelines (IYCF), introduction of CF was assessed as the proportion of infants aged 6-8 months who received solid, semi-solid or soft foods. Search terms were: \"children\", \"feeding\" and \"Asians\" with their derivatives. Two researchers undertook study selection, data extraction and quality appraisal.
    RESULTS: Three cohort, 30 cross-sectional and 3 mixed methods studies were included. Despite adopting the WHO IYCF Guidelines, sub-optimal CF practices were found in many studies. Timely initiation of CF practices ranged from 24 to 83%. Achieved minimum dietary diversity ranged from 25% to 44% and minimum meal frequency from 33% to 81%. Influencing factors included maternal education, poor knowledge of CF practices and socioeconomic variables.
    CONCLUSIONS: This is the first systematic review to evaluate CF practices in Bangladesh. Despite adoption of the WHO IYCF guidelines, inadequate CFP remain in communities across Bangladesh.
    BACKGROUND: PROSPERO Registration No: CRD42014014025.
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  • 文章类型: Journal Article
    呼气冷凝液是一种很有前途的,非侵入性,通过呼气冷凝获得的诊断样本。从呼吸测试的早期尝试的历史角度出发,以进行当代最先进的呼吸分析,本文主要综述了呼气冷凝液中非挥发性化合物的检测进展。讨论了在气道中形成非挥发性化合物的气溶胶/液滴的机制,并对采样产生了方法学后果。呼吸液滴的稀释是测量数据的正确临床解释的主要问题,并且迫切需要EBC的标准化。这也适用于收集仪器,因此描述了各种商业和内部构建的设备,并就其设计进行了比较。函数和集合参数。对作为氧化应激和肺部炎症潜在标志物的非挥发性化合物的分析技术和方法进行了审查,重点是方法适用性。敏感性和适当性。给出了每组可能的非挥发性肺部疾病标志物的临床发现的相关性,以及方法学建议,重点是跨学科合作,这对于将来发展为经过充分验证的临床诊断工具至关重要。
    Exhaled breath condensate is a promising, non-invasive, diagnostic sample obtained by condensation of exhaled breath. Starting from a historical perspective of early attempts of breath testing towards the contemporary state-of-the-art breath analysis, this review article focuses mainly on the progress in determination of non-volatile compounds in exhaled breath condensate. The mechanisms by which the aerosols/droplets of non-volatile compounds are formed in the airways are discussed with methodological consequences for sampling. Dilution of respiratory droplets is a major problem for correct clinical interpretation of the measured data and there is an urgent need for standardization of EBC. This applies also for collection instrumentation and therefore various commercial and in-house built devices are described and compared with regard to their design, function and collection parameters. The analytical techniques and methods for determination of non-volatile compounds as potential markers of oxidative stress and lung inflammation are scrutinized with an emphasis on method suitability, sensitivity and appropriateness. The relevance of clinical findings for each group of possible non-volatile markers of selected pulmonary diseases and methodological recommendations with emphasis on interdisciplinary collaboration that is essential for future development into a fully validated clinical diagnostic tool are given.
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  • 文章类型: Journal Article
    硒是生物体正常细胞功能的基本要素。然而,硒的毒性浓度仅比必需浓度高3至5倍。环境水中存在的无机形式(主要是亚硒酸盐和硒酸盐)通常表现出比有机形式更高的毒性(高达40倍)。因此,测定水中低水平的不同无机硒是一个分析挑战。在确定硒物质之前,固相萃取已被用作分离和/或预浓缩技术,因为需要精确测量极低含量的水中硒物质。本文对已发表的使用固相萃取作为预浓缩程序的水样中无机硒形态形成方法进行了严格的评论。根据超过75个参考文献,用于此任务的不同物种形成策略已被强调和分类。还讨论了固相萃取吸附剂以及已开发的Se形态形成方法的性能和分析特征。
    Selenium is an essential element for the normal cellular function of living organisms. However, selenium is toxic at concentrations of only three to five times higher than the essential concentration. The inorganic forms (mainly selenite and selenate) present in environmental water generally exhibit higher toxicity (up to 40 times) than organic forms. Therefore, the determination of low levels of different inorganic selenium species in water is an analytical challenge. Solid-phase extraction has been used as a separation and/or preconcentration technique prior to the determination of selenium species due to the need for accurate measurements for Se species in water at extremely low levels. The present paper provides a critical review of the published methods for inorganic selenium speciation in water samples using solid phase extraction as a preconcentration procedure. On the basis of more than 75 references, the different speciation strategies used for this task have been highlighted and classified. The solid-phase extraction sorbents and the performance and analytical characteristics of the developed methods for Se speciation are also discussed.
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