Bronchial Diseases

  • 文章类型: Journal Article
    背景:支气管Dieulafoy病(BDD),一种很少报道的疾病,来自支气管粘膜下扩张或异常的动脉。BDD患者通常无症状,因此该疾病经常被误诊。然而,粘膜下动脉可能因各种原因扩张和破裂,导致反复呼吸道出血和可能危及生命的疾病。随着血管内压等可逆因素的变化,动脉可能会恢复正常,让患者恢复到无症状状态。这一现象在以往的研究中没有被提及和关注,但它可能对我们正确认识这种疾病有重要意义。
    方法:一名44岁的女性因复发性恶性心律失常入院重症监护病房。在VA-体外膜氧合(ECMO)的协助下,她的生命体征和内部环境都逐渐稳定。然而,她经历了反复的呼吸道出血。在用纤维支气管镜去除血腥分泌物的同时,在患者的左主支气管壁上发现了一个充血的突出颗粒。
    方法:患者被诊断为BDD,颗粒被认为是BDD的异常动脉。
    方法:对于患者的病情,我们未对异常动脉实施任何针对性干预.
    结果:VA-ECMO断奶后,患者的颗粒找不到,出血也消失了。她逐渐戒断机械通气,转到心内科。患者病情稳定后出院。在半年多的时间里,病人身体状况正常。
    结论:异常动脉的出现和消失是BDD的一个有趣现象。由于各种原因如VA-ECMO引起的血管内压的变化可能是其主要因素。
    BACKGROUND: Bronchial Dieulafoy disease (BDD), a rarely reported disease, comes from dilated or abnormal arteries under the bronchial mucosa. Patients with BDD are generally asymptomatic so this disease is frequently misdiagnosed. However, the submucosal arteries may dilate and rupture for various reasons, leading to recurrent respiratory tract bleeding and potentially life-threatening conditions. With the change of reversible factors such as intravascular pressure, the arteries may return to normal, allowing patients to recover to an asymptomatic state. This phenomenon has not been mentioned and concerned in previous studies, but it may have important implications for our correct understanding of this disease.
    METHODS: A 44-year-old female was admitted to intensive care unit with recurrent malignant arrhythmias. With the assistance of VA-extracorporeal membrane oxygenation (ECMO), both her vital signs and internal environment were all gradually stabilized. However, she had been experiencing recurrent respiratory tract bleeding. While removing the bloody secretion with a fiber bronchoscopy, a congested protruding granule on the wall of the patient\'s left principal bronchus was found.
    METHODS: The patient was diagnosed with BDD and the granule was thought to be an abnormal artery of BDD.
    METHODS: For the patient\'s condition, we did not implement any targeted interventions with the abnormal artery.
    RESULTS: After the weaning of VA-ECMO, the patient\'s granule could not be found and the bleeding had also disappeared. She gradually weaned off the mechanical ventilation and was transferred to the Department of Cardiology. Then the patient was discharged after her condition stabilized. In more than half a year, the patient is in a normal physical condition.
    CONCLUSIONS: The appearance and disappearance of abnormal artery is an interesting phenomena of BDD. The change of intravascular pressure due to various causes such as VA-ECMO may be the primary factor of it.
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  • 文章类型: Journal Article
    炎症性肠病(IBD)的胸部表现很少见,发生在不到1%的患者中。与大多数其他肠外表现不同,它们在溃疡性结肠炎患者中占主导地位,而不是克罗恩病。在大多数患者中,在IBD发病后几年,胸部受累。然而,胸部受累也可能同时发生,甚至在消化道症状发作之前发生。IBD的胸部表现包括气道受累和肺实质异常。气道是IBD胸部受累的最常见解剖部位。气道表现通常在肠道表现发作后几年发展,优先当后者是稳定的或在缓解。气道表现包括支气管壁增厚,支气管扩张,小气道疾病,和气管壁增厚。实质性肺异常在IBD中较不常见,包括机化性肺炎,坏死性结节,非干酪性肉芽肿结节,药物性肺炎,很少有间质性肺病.机化性肺炎之间的鉴别诊断,坏死性结节,非干酪性肉芽肿性结节很难,通常需要进行组织病理学分析才能明确诊断。放射科医师在克罗恩病和溃疡性结肠炎的胸部表现的检测中发挥关键作用,因此,需要熟悉他们的影像学发现。本文旨在概述克罗恩病或溃疡性结肠炎患者胸部表现的影像学表现。关键相关声明:克罗恩病和溃疡性结肠炎的胸部表现包括气管受累,支气管扩张,小气道疾病,和肺实质异常,如机化性肺炎和坏死性结节。这些罕见的表现(<1%的患者)更常影响溃疡性结肠炎患者。要点:炎症性肠病的胸部表现很少见,发生在不到1%的患者中。溃疡性结肠炎患者的胸部表现比克罗恩病更常见。支气管疾病是克罗恩病和溃疡性结肠炎最常见的胸部表现。
    Thoracic manifestations of inflammatory bowel disease (IBD) are rare, occurring in less than 1% of patients. Unlike most other extra-intestinal manifestations, they predominate in patients with ulcerative colitis rather than in Crohn\'s disease. In most patients, thoracic involvement follows the onset of IBD by several years. However, thoracic involvement may also occur synchronously or even precede the onset of digestive symptoms. The thoracic manifestations of IBD include airway involvement and parenchymal lung abnormalities. Airways are the most frequent anatomical site for thoracic involvement in IBD. Airway manifestations usually develop several years after the onset of intestinal manifestations, preferentially when the latter are stable or in remission. Airway manifestations include bronchial wall thickening, bronchiectasis, small airway disease, and tracheal wall thickening. Parenchymal lung abnormalities are less prevalent in IBD and include organizing pneumonia, necrobiotic nodules, noncaseating granulomatous nodules, drug-induced pneumonia, and rarely interstitial lung diseases. The differential diagnosis between organizing pneumonia, necrobiotic nodules, and noncaseating granulomatous nodules is difficult and usually requires histopathological analysis for a definite diagnosis. Radiologists play a key role in the detection of thoracic manifestations of Crohn\'s disease and ulcerative colitis and, therefore, need to be familiar with their imaging findings. This article aims to offer an overview of the imaging findings of thoracic manifestations in patients with Crohn\'s disease or ulcerative colitis. CRITICAL RELEVANCE STATEMENT: Thoracic manifestations of Crohn\'s disease and ulcerative colitis include tracheal involvement, bronchiectasis, small airway disease, and parenchymal lung abnormalities such as organizing pneumonia and necrobiotic nodules. These rare manifestations (< 1% of patients) more often affect patients with ulcerative colitis. KEY POINTS: Thoracic manifestations of inflammatory bowel disease are rare, occurring in less than 1% of patients. Thoracic manifestations are more frequent in patients with ulcerative colitis than Crohn\'s disease. Bronchial disease is the most frequent thoracic manifestation of Crohn\'s disease and ulcerative colitis.
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  • 文章类型: Case Reports
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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
    一只2岁被阉割的俄罗斯蓝猫食欲不振,抑郁症,和费力的呼吸。X线检查结果提示左肺不张;然而,超声检查结果未提示肺不张.左肺动脉(PA)在超声心动图上异常小;进一步,没有其他心脏异常.计算机断层扫描显示左PA和左肺异常小。此外,在肺叶中观察到支气管扩张和芽中树的模式。基于这些发现,这只猫被诊断出患有孤立的左PA发育不全,推测左肺发育不全,和猫慢性支气管疾病。这种疾病的早期诊断很重要,因为它会导致严重的并发症,包括反复呼吸道感染,支气管扩张,大咯血,和肺动脉高压。
    A 2-year-old castrated Russian Blue cat presented with inappetence, depression, and labored respirations. Radiography findings suggested left lung atelectasis; however, the ultrasonography findings did not indicate lung atelectasis. The left pulmonary artery (PA) was abnormally small on echocardiography; further, there were no other cardiac anomalies. Computed tomography revealed an abnormally small left PA and left lung. Furthermore, bronchiectasis and tree-in-bud patterns were observed in the lung lobes. Based on these findings, the cat was diagnosed with isolated left PA hypoplasia, presumed left lung hypoplasia, and feline chronic bronchial disease. Early diagnosis of this disease is important because it can cause serious complications, including recurrent respiratory infection, bronchiectasis, massive hemoptysis, and pulmonary hypertension.
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  • 文章类型: Journal Article
    大型气道疾病包括多种疾病和病理,包括解剖变异在内的广泛类别,先天性异常,获得性异常,炎症/浸润原因,感染,和肿瘤。讨论了每个类别中最常见的疾病,重点是突出的影像学发现。通过文章讨论了要注意的陷阱,并总结了一种接近大型气道病理学的一般方法,该方法应该为读者提供一个基本的框架和对这个复杂主题的理解。
    Large airway disorders encompass a large variety of diseases and pathology, with broad categories including anatomic variants, congenital abnormalities, acquired abnormalities, inflammatory/infiltrative causes, infection, and tumors. The most common diseases in each category are discussed with a focus on the salient imaging findings. Pitfalls to beware of are discussed through the article, and concludes with a general method to approaching large airways pathology that should provide the reader with a basic framework and understanding of this complex topic.
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  • 文章类型: Case Reports
    纳入研究的2例患者患有混合型和难治性结核后气管支气管狭窄(PTTS),术前经历过球囊扩张和V形支架置入等不成功的介入治疗。安全放置L形硅胶支架后,术后第1个月和第3个月的纤维支气管镜检查显示,两名患者的支气管粘膜炎症均显着减少。此外,上部和下部分支段的开口直径增加,胸部CT扫描显示左肺病变明显吸收。手术后三个月,纤维支气管镜检查证实支架固定稳定,无任何运动。患者的肺功能有了实质性的改善,呼吸困难指数,和血气分析,没有报告的不良并发症。7个月后,1例纤维支气管镜随访显示支架固定效果良好。同时,胸部CT扫描显示有利的再扩张。L形硅胶支架的放置证明可有效防止移位,缓解气道狭窄或阻塞,并确保PTTS治疗的安全性和有效性-特别是在V形硅胶支架置入失败的情况下。据我们所知,这是第一项描述2例PTTS患者使用L型硅胶支架的研究.
    使用特殊的L形硅胶支架成功治疗因肺结核引起的严重气道狭窄本文讲述了两名患有肺结核后气管支气管狭窄(PTS)的复杂肺部疾病的患者的故事。想象一下你的气道-将空气输送到肺部的管道-由于过去的肺结核发作而严重伤痕累累并变窄。这两名患者尝试了以前的治疗方法,如球囊扩张(在狭窄的气道内膨胀一个小球囊以使其变宽)和使用V形支架(放置在气道中以保持其打开的柔性支撑),但是这些方法并不能提供持久的缓解。在这种创新的方法中,医生使用了专门设计用于患者气道受影响部位的L形硅胶支架。放置这些支架后,定期检查显示出显着的改善。气道内膜肿胀明显减轻,通向肺部上部和下部的开口变得更宽。胸部X光片(CT扫描)甚至显示患者的左肺愈合良好。三个月后,支架牢牢地保持在原位,两个病人都没有遇到任何问题。呼吸变得更容易,肺功能检查有所改善,血液测试显示氧气水平更好。七个月后,一名患者继续做得非常好,支架牢固固定,胸部扫描显示肺部扩张良好。这项开创性的研究表明,当其他方法失败时,使用L形硅胶支架可以有效治疗PTTS。他们不仅呆在原地,防止堵塞,但它们也安全有效地缓解了气道狭窄。这是第一次在PTTS患者中成功使用这种L形支架,为面临类似挑战的人们带来新的希望。
    The two patients included in the study had mixed and refractory post-tuberculosis tracheobronchial stenosis (PTTS), having experienced unsuccessful interventional therapies such as balloon dilation and V-shaped stent placement before the operation. Following the secure placement of L-shaped silicone stents, examinations with a fiberbronchoscope during the first and third months post-operation revealed a significant reduction in bronchial mucosa inflammation for both patients. Additionally, the opening diameter of the upper and lower branch segments increased, and chest CT scans indicated a noticeable absorption of left pulmonary lesions. Three months post-operation, fiberbronchoscopy confirmed the stable fixation of the stent without any movement. The patients exhibited substantial improvements in pulmonary function, dyspnea index, and blood gas analysis, with no reported adverse complications. After 7 months, a follow-up fiberbronchoscope for one case revealed excellent stent fixation. Simultaneously, the chest CT scan indicated favorable re-expansion. The placement of L-shaped silicone stents proves effective in preventing displacement, alleviating airway stenosis or obstruction, and ensuring the safety and efficacy of PTTS treatment - particularly in cases where V-shaped silicone stent placement has failed. To our knowledge, this is the first study describing the L-shaped silicone stent in two patients with PTTS.
    Successful treatment of severe airway narrowing due to tuberculosis using special L-shaped silicone stentsThis article tells the story of two patients who suffered from a complex lung condition called post-tuberculosis tracheobronchial stenosis (PTTS). Imagine your airways - the tubes that carry air to your lungs - getting severely scarred and narrowed due to a past bout with tuberculosis. These two patients had tried previous treatments like balloon dilation (where a small balloon is inflated inside the narrowed airway to widen it) and using V-shaped stents (flexible supports placed in the airway to keep it open), but these methods didn’t provide lasting relief. In this innovative approach, doctors used L-shaped silicone stents specifically designed to fit in the affected parts of the patients’ airways. After placing these stents, regular checks showed remarkable improvements. The swelling in the airway lining reduced significantly, and the openings leading to the upper and lower parts of the lungs got wider. Chest X-rays (CT scans) even showed that the patient’s left lung was healing well. Three months later, the stents stayed firmly in place, and neither patient experienced any problems. Breathing became easier, lung function tests improved, and blood tests showed better oxygen levels. Seven months down the line, one patient continued to do extremely well, with the stent securely fixed and the chest scan showing good lung expansion. This groundbreaking study shows that using L-shaped silicone stents can effectively treat PTTS when other methods fail. Not only do they stay in place, preventing blockages, but they also safely and effectively alleviate narrowing of the airways. It’s the first time such L-shaped stents have been used successfully in PTTS patients, offering new hope for those facing similar challenges.
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  • 文章类型: English Abstract
    复发性多软骨炎是一种全身性自身免疫性疾病,主要影响软骨结构,通过缓解期之间的炎症发作进展,并最终导致所涉及的软骨变形。除了耳廓或鼻软骨的特征性损伤外,气管支气管和心脏受累特别严重,并能严重改变预后.通过多模式方法评估气管支气管病变,包括动态胸部成像,肺功能的测量(最近强调脉搏振荡法),并通过柔性支气管镜绘制气管病变图。在缺乏特定诊断工具的情况下,诊断可能很困难。尤其是可能存在大量的鉴别诊断,特别是关于炎症性疾病。预后有所改善,主要由于介入性支气管镜检查技术的升级以及免疫抑制剂药物和靶向治疗的发展,为患者提供多种治疗选择。
    Relapsing polychondritis is a systemic auto-immune disease that mainly affects cartilage structures, progressing through inflammatory flare-ups between phases of remission and ultimately leading to deformation of the cartilages involved. In addition to characteristic damage of auricular or nasal cartilage, tracheobronchial and cardiac involvement are particularly severe, and can seriously alter the prognosis. Tracheobronchial lesions are assessed by means of a multimodal approach, including dynamic thoracic imaging, measurement of pulmonary function (with recent emphasis on pulse oscillometry), and mapping of tracheal lesions through flexible bronchoscopy. Diagnosis can be difficult in the absence of specific diagnostic tools, especially as there may exist a large number of differential diagnoses, particularly as regards inflammatory diseases. The prognosis has improved, due largely to upgraded interventional bronchoscopy techniques and the development of immunosuppressant drugs and targeted therapies, offering patients a number of treatment options.
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    文章类型: Case Reports
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