目的:描述两种剂量的马罗匹坦对疼痛评分的影响,食物摄入量,接受选择性卵巢子宫切除术或睾丸切除术的家兔(猪)的粪便排出量。
方法:26(11名女性,来自三个机构的15只雄性)兔子。
方法:兔子被随机分配到三个治疗组之一:低剂量马罗匹坦(LDM;2mg/kgSC一次;n=8),中等剂量马罗匹坦(MDM;4mg/kgSC一次;n=10),和对照(盐水相当于4mg/kg马罗匹坦SC一次;n=8),手术前给药。手术后,所有家兔肌内注射丁丙诺啡(0.06mg/kg,q8小时)和美洛昔康(1mg/kg,q24小时).术后使用视频监控对兔子进行监控,直到手术或出院后24小时,以先到者为准。疼痛评分由三名失明的观察者评估,结果分为早期(0-4小时),中期(5-8小时),和延迟(12-24小时)的时间框架。比较各组的食物摄入和粪便排出量。使用卡方进行统计分析,费希尔的精确检验,和混合模型方法。
结果:马罗匹坦给药没有不良反应。与对照组相比,接受MDM的兔子在中期范围内的疼痛评分和在后期范围内的行为评分显着降低。雄性兔子比雌性兔子消耗更多的食物,住院时间超过12小时的兔子比以前出院的兔子消耗更多的食物。面部表情量表评分无显著差异,食物摄入量,或治疗组之间的粪便产生。
结论:中等剂量的马洛匹坦降低了手术后中期疼痛相关行为和后期行为评分。需要进一步的研究来更好地表征马罗匹坦在术后镇痛中的潜在用途。
OBJECTIVE: To describe the effect of two doses of maropitant on pain scores, food intake, and fecal output in domestic rabbits (Oryctolagus cuniculus) undergoing elective ovariohysterectomy or orchiectomy.
METHODS: 26 (11 female, 15 male) rabbits from three institutions.
METHODS: Rabbits were randomly assigned to one of three treatment groups: low-dose maropitant (LDM; 2 mg/kg SC once; n=8), moderate-dose maropitant (MDM; 4 mg/kg SC once; n=10), and control (saline equivalent to 4 mg/kg maropitant SC once; n=8), administered prior to surgery. Following surgery, all rabbits were provided buprenorphine (0.06 mg/kg q 8 hours) and meloxicam (1 mg/kg q 24 hours) intramuscularly. Rabbits were monitored using video surveillance postoperatively until 24 hours after surgery or discharge from the hospital, whichever came first. Pain scores were assessed by three blinded observers, and results were grouped into early (0-4 hours), mid (5-8 hours), and late (12-24 hours) time frames. Food intake and fecal output were compared between groups. Statistical analysis was performed using Chi square, Fisher\'s exact tests, and a mixed model approach.
RESULTS: There were no adverse effects with maropitant administration. Rabbits that received MDM had significantly lower pain scores in the mid-time frame and
behavior scores in the late-time frame compared to controls. Male rabbits consumed more food than females and rabbits hospitalized longer than 12 hours consumed more food than those that were discharged prior. No significant differences were detected in facial grimace scale scores, food intake, or fecal production among treatment groups.
CONCLUSIONS: Moderate dose maropitant decreased pain related behaviors in the mid-time frame and
behavior scores in the late-time frame after surgery. Further studies are necessary to better characterize the potential use of maropitant in postoperative analgesia.