Abstract：
UNASSIGNED: The present study aims to evaluate the impact of early exposure to brain injury and malnutrition on episodic memory and behavior.
UNASSIGNED: For this, a systematic review was carried out in the Medline/Pubmed, Web of Science, Scopus, and LILACS databases with no year or language restrictions.
UNASSIGNED: Initially, 1759 studies were detected. After screening, 53 studies remained to be read in full. The meta-analysis demonstrated that exposure to double insults worsens episodic recognition memory but does not affect spatial memory. Early exposure to low-protein diets has been demonstrated to aggravate locomotor and masticatory sequelae. Furthermore, it reduces the weight of the soleus muscle and the muscle fibers of the masseter and digastric muscles. Early exposure to high-fat diets promotes an increase in oxidative stress and inflammation in the brain, increasing anxiety- and depression-like behavior and reducing locomotion.
UNASSIGNED: Epigenetic modifications were noted in the hippocampus, hypothalamus, and prefrontal cortex depending on the type of dietetic exposure in early life. These findings demonstrate the impact of the double insult on regions involved in cognitive and behavioral processes. Additional studies are essential to understand the real impact of the double insults in the critical period.
UNASSIGNED: For this, a systematic review was carried out in the Medline/Pubmed, Web of Science, Scopus, and LILACS databases with no year or language restrictions.
UNASSIGNED: Initially, 1759 studies were detected. After screening, 53 studies remained to be read in full. The meta-analysis demonstrated that exposure to double insults worsens episodic recognition memory but does not affect spatial memory. Early exposure to low-protein diets has been demonstrated to aggravate locomotor and masticatory sequelae. Furthermore, it reduces the weight of the soleus muscle and the muscle fibers of the masseter and digastric muscles. Early exposure to high-fat diets promotes an increase in oxidative stress and inflammation in the brain, increasing anxiety- and depression-like behavior and reducing locomotion.
UNASSIGNED: Epigenetic modifications were noted in the hippocampus, hypothalamus, and prefrontal cortex depending on the type of dietetic exposure in early life. These findings demonstrate the impact of the double insult on regions involved in cognitive and behavioral processes. Additional studies are essential to understand the real impact of the double insults in the critical period.
摘要：
■本研究旨在评估早期暴露于脑损伤和营养不良对情景记忆和行为的影响。
■为此，在Medline/Pubmed，WebofScience,Scopus,和LILACS数据库没有年份或语言限制。
■最初，共检测到1759项研究。筛选后,53项研究仍有待全文阅读。荟萃分析表明，暴露于双重伤害会恶化情节识别记忆，但不会影响空间记忆。已证明早期接触低蛋白饮食会加重运动和咀嚼后遗症。此外，它减轻了比目鱼肌和咬肌和腹肌的肌纤维的重量。早期接触高脂肪饮食会促进大脑中氧化应激和炎症的增加，增加焦虑和抑郁样行为，减少运动。
■在海马中注意到表观遗传修饰，下丘脑,和前额叶皮层取决于早期饮食暴露的类型。这些发现证明了双重侮辱对涉及认知和行为过程的区域的影响。进一步的研究对于了解关键时期双重侮辱的实际影响至关重要。
■为此，在Medline/Pubmed，WebofScience,Scopus,和LILACS数据库没有年份或语言限制。
■最初，共检测到1759项研究。筛选后,53项研究仍有待全文阅读。荟萃分析表明，暴露于双重伤害会恶化情节识别记忆，但不会影响空间记忆。已证明早期接触低蛋白饮食会加重运动和咀嚼后遗症。此外，它减轻了比目鱼肌和咬肌和腹肌的肌纤维的重量。早期接触高脂肪饮食会促进大脑中氧化应激和炎症的增加，增加焦虑和抑郁样行为，减少运动。
■在海马中注意到表观遗传修饰，下丘脑,和前额叶皮层取决于早期饮食暴露的类型。这些发现证明了双重侮辱对涉及认知和行为过程的区域的影响。进一步的研究对于了解关键时期双重侮辱的实际影响至关重要。
