这个双中心,回顾性分析研究了PET/CT与一种新的治疗性前列腺特异性膜抗原(PSMA)-靶向配体的疗效,18F-rhPSMA-7,在根治性初次放疗后前列腺癌生化复发(BCR)患者中。方法:在慕尼黑工业大学或慕尼黑路德维希-马克西米利安大学接受18F-rhPSMA-7PET/CT的外束放射治疗或近距离放射治疗后前列腺癌BCR患者的数据集,由经验丰富的核医学医师和放射科医师进行回顾性审查在两个中心。中位注射活性为299MBq(范围,204-420MBq),中位摄取时间为77分钟(范围,46-120分钟)。注意到所有提示复发性前列腺癌的病变。检出率与患者前列腺特异性抗原(PSA)水平相关,主要格里森分数,和先前使用雄激素剥夺疗法(ADT)。结果:共纳入97例患者(慕尼黑工业大学65例,慕尼黑路德维希-马克西米利安大学32例)。预扫描PSA中位数为4.19ng/mL(范围,0.1-159ng/mL)。19例患者的主要Gleason评分≤6分,25人中7人,33人中≥8人,20人中未知。30例患者在PET/CT前6个月接受ADT。18F-rhPSMA-7在97例患者中的91例(94%)中发现了病变。按PSA分层的检出率为88%(22/25),97%(30/31),90%(19/21),PSA<2、2-<5、5-<10和≥10ng/mL时,为100%(20/20),分别。不符合PhoenixBCR标准的患者亚组的检出率为80%(4/5),90%(9/10),100%(4/4)对于PSA<0.5、0.5-<1、1-<1.5和1.5-2ng/mL,则为83%(5/6),分别。有和没有ADT的患者之间的检出率没有显着差异(100%vs.91%,P=0.173)或Gleason评分≤7且Gleason评分≥8的患者(98%vs.91%,18F-rhPSMA-7显示局部复发80%(78/97),盆腔淋巴结转移38%(37/97),腹膜后和膈上淋巴结转移9%(9/97)和4%(4/97),分别为27%(26/97)的骨转移和3%的内脏转移(3/97)。在PSA高于最低点<2ng/mL的患者亚组中,76%(19/25)发生局部复发,36%(9/25)发生盆腔淋巴结转移.结论:18F-rhPSMA-7PET/CT对前列腺癌患者放疗后BCR的检出率较高,即使在低PSA值。其诊断功效与其他PSMA配体的公开数据相当。
This bicentric, retrospective analysis investigated the efficacy of PET/CT with a novel theranostic prostate-specific membrane antigen (PSMA)--targeting ligand, 18F-rhPSMA-7, in patients with biochemical recurrence (
BCR) of prostate cancer after curative-intent primary radiotherapy. Methods: Datasets from patients with
BCR of prostate cancer after external-beam radiation therapy or brachytherapy who underwent 18F-rhPSMA-7 PET/CT at either Technical University Munich or Ludwig-Maximilians-University Munich were retrospectively reviewed by experienced nuclear medicine physicians and radiologists at both centers. The median injected activity was 299 MBq (range, 204-420 MBq), and the median uptake time was 77 min (range, 46-120 min). All lesions suggestive of recurrent prostate cancer were noted. Detection rates were correlated with patients\' prostate-specific antigen (PSA) level, primary Gleason score, and prior use of androgen-deprivation therapy (ADT). Results: Ninety-seven patients were included (65 at Technical University Munich and 32 at Ludwig-Maximilians-University Munich). The median prescan PSA was 4.19 ng/mL (range, 0.1-159 ng/mL). The primary Gleason score was ≤6 in 19 patients, 7 in 25, ≥8 in 33, and unknown in 20. Thirty patients received ADT in the 6 mo preceding PET/CT. 18F-rhPSMA-7 identified lesions in 91 of 97 (94%) patients. Detection rates stratified by PSA were 88% (22/25), 97% (30/31), 90% (19/21), and 100% (20/20) for a PSA of <2, 2-<5, 5-<10, and ≥10 ng/mL, respectively. Detection rates in the subgroup of patients not meeting the Phoenix criteria for
BCR were 80% (4/5), 90% (9/10), 100% (4/4), and 83% (5/6) for a PSA of <0.5, 0.5-<1, 1-<1.5, and 1.5-2 ng/mL, respectively. There were no significant differences in detection rates between patients with and without prior ADT (100% vs. 91%, P = 0.173) or patients with a Gleason score of ≤7 and a Gleason score of ≥8 (98% vs. 91%, P = 0.316).18F-rhPSMA-7 revealed local recurrence in 80% (78/97); pelvic lymph node metastases in 38% (37/97); retroperitoneal and supradiaphragmatic lymph node metastases in 9% (9/97) and 4% (4/97), respectively; bone metastases in 27% (26/97); and visceral metastases in 3% (3/97). In the subgroup of patients with a PSA of <2 ng/mL above nadir, local recurrence occurred in 76% (19/25) and pelvic lymph node metastases in 36% (9/25). Conclusion:18F-rhPSMA-7 PET/CT demonstrates high detection rates in prostate cancer patients with
BCR after primary radiation therapy, even at low PSA values. Its diagnostic efficacy is comparable to published data for other PSMA ligands.