Abstract：
BACKGROUND: Existing models for predicting that biochemical recurrence (BCR) will occur in patients after radical prostatectomy (RP) vary in their predictive results from magnetic resonance imaging (MRI). This study aimed to assess the predictive value of preoperative prostate-specific antigen (PSA) levels combined with MRI features in determining BCR following radical prostatectomy.
METHODS: A retrospective analysis was conducted on a cohort comprising 102 patients who underwent radical prostatectomy at our hospital between January 2019 and December 2019. On the basis of the outcomes observed during a 4-year follow-up after surgery, the patients were categorised into BCR group (n = 52) and non-BCR group (n = 50). Differences in preoperative PSA levels and MRI characteristics between the two groups were compared, and factors influencing postoperative BCR were analysed. The receiver operating characteristic curve was drawn, and the sensitivity, specificity, area under the curve (AUC) and Youden index were calculated to observe the predictive value of the combination of preoperative PSA level and MRI features for BCR following radical prostatectomy.
RESULTS: Logistic regression analysis showed that preoperative PSA level, postoperative Gleason score, data system (Prostate Imaging-Reporting and Data System (PI-RADS)) score and clinical T stage were independent risk factors for BCR in patients following radical prostatectomy, with odds ratio (OR) greater than 1. The AUC value of preoperative PSA level combined with PI-RADS score was 0.921, surpassing the AUC values of 0.783, 0.822, 0.617 and 0.608 predicted by preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage alone, respectively.
CONCLUSIONS: Postoperative BCR in patients with prostate cancer undergoing radical prostatectomy is associated with preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage. The combination of preoperative PSA level and MRI features can improve the predictive efficiency for postoperative BCR.
METHODS: A retrospective analysis was conducted on a cohort comprising 102 patients who underwent radical prostatectomy at our hospital between January 2019 and December 2019. On the basis of the outcomes observed during a 4-year follow-up after surgery, the patients were categorised into BCR group (n = 52) and non-BCR group (n = 50). Differences in preoperative PSA levels and MRI characteristics between the two groups were compared, and factors influencing postoperative BCR were analysed. The receiver operating characteristic curve was drawn, and the sensitivity, specificity, area under the curve (AUC) and Youden index were calculated to observe the predictive value of the combination of preoperative PSA level and MRI features for BCR following radical prostatectomy.
RESULTS: Logistic regression analysis showed that preoperative PSA level, postoperative Gleason score, data system (Prostate Imaging-Reporting and Data System (PI-RADS)) score and clinical T stage were independent risk factors for BCR in patients following radical prostatectomy, with odds ratio (OR) greater than 1. The AUC value of preoperative PSA level combined with PI-RADS score was 0.921, surpassing the AUC values of 0.783, 0.822, 0.617 and 0.608 predicted by preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage alone, respectively.
CONCLUSIONS: Postoperative BCR in patients with prostate cancer undergoing radical prostatectomy is associated with preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage. The combination of preoperative PSA level and MRI features can improve the predictive efficiency for postoperative BCR.
摘要：
背景：用于预测根治性前列腺切除术（RP）后患者将发生生化复发（BCR）的现有模型在磁共振成像（MRI）的预测结果上有所不同。这项研究旨在评估术前前列腺特异性抗原（PSA）水平结合MRI特征在确定根治性前列腺切除术后BCR中的预测价值。
方法：对2019年1月至2019年12月在我院接受前列腺癌根治术的102例患者进行回顾性分析。根据手术后4年随访期间观察到的结果，将患者分为BCR组(n=52)和非BCR组(n=50).比较两组患者术前PSA水平及MRI表现,分析影响术后BCR的因素。绘制了接收机工作特性曲线,和灵敏度，特异性，计算曲线下面积（AUC）和Youden指数，以观察术前PSA水平和MRI特征对前列腺癌根治术后BCR的预测价值。
结果：Logistic回归分析显示术前PSA水平,术后Gleason评分,数据系统（前列腺成像报告和数据系统（PI-RADS））评分和临床T分期是前列腺癌根治术后患者BCR的独立危险因素，比值比(OR)大于1。术前PSA水平联合PI-RADS评分的AUC值为0.921,超过术前PSA水平预测的AUC值为0.783、0.822、0.617和0.608,术后Gleason评分,PI-RADS评分和临床T分期,分别。
结论：前列腺癌根治术患者术后BCR与术前PSA水平相关，术后Gleason评分,PI-RADS评分与临床T分期有关。术前PSA水平与MRI特征相结合可提高术后BCR的预测效率。
方法：对2019年1月至2019年12月在我院接受前列腺癌根治术的102例患者进行回顾性分析。根据手术后4年随访期间观察到的结果，将患者分为BCR组(n=52)和非BCR组(n=50).比较两组患者术前PSA水平及MRI表现,分析影响术后BCR的因素。绘制了接收机工作特性曲线,和灵敏度，特异性，计算曲线下面积（AUC）和Youden指数，以观察术前PSA水平和MRI特征对前列腺癌根治术后BCR的预测价值。
结果：Logistic回归分析显示术前PSA水平,术后Gleason评分,数据系统（前列腺成像报告和数据系统（PI-RADS））评分和临床T分期是前列腺癌根治术后患者BCR的独立危险因素，比值比(OR)大于1。术前PSA水平联合PI-RADS评分的AUC值为0.921,超过术前PSA水平预测的AUC值为0.783、0.822、0.617和0.608,术后Gleason评分,PI-RADS评分和临床T分期,分别。
结论：前列腺癌根治术患者术后BCR与术前PSA水平相关，术后Gleason评分,PI-RADS评分与临床T分期有关。术前PSA水平与MRI特征相结合可提高术后BCR的预测效率。
