未经证实:肠外致病性大肠杆菌(ExPEC)是侵袭性疾病的主要原因,包括菌血症和败血症.侵袭性ExPEC疾病(IED)有可能使其他疾病的临床治疗复杂化,并与死亡率增加有关。住院治疗,更糟糕的结果。老年人和患有共病的个体患IED的风险较高。由于人口老龄化和抗菌素耐药性上升,ExPEC在亚太地区受到特别关注。
未经评估:本研究旨在综合流行病学的最新数据,中国老年人/高危人群IED的临床和经济负担,Japan,韩国,台湾,和澳大利亚。
UNASSIGNED:使用Embase进行了有针对性的文献综述,Medline以及当地的科学数据库。我们纳入了2010年1月1日至2020年10月7日以英语和当地语言发表的与研究目标相关的研究。研究是叙述性综合的。
UNASSIGNED:共确定了1,047项研究,其中34项纳入本综述。在韩国60岁以上的患者中,ExPEC占细菌相关侵袭性疾病的46.0%(1,238/2,692),其次是中国(44.4%(284/640)),台湾(39.0%(1,244/3,194)),和日本(18.1%(581/3,206)),而澳大利亚在一般成年人中报告了所有病原体中的ExPEC(54.7%(4,006/7,330))。糖尿病或癌症等合并症在这些患者中很常见。研究报告了住院时间的增加,与ExPEC相关菌血症相关的住院30日全因死亡率为9%~12%.从成本的角度来看,据报道,2005-2012年间,韩国脓毒症相关费用增加了3倍.在澳大利亚,抗菌素耐药性导致每年580万澳元的额外成本(95%不确定区间[UI],2.2-1,120万美元)用于治疗血流感染(BSIs)。
未经证实:ExPEC是中国各地血流感染的主要原因,Japan,韩国,台湾,和澳大利亚。与ExPEC感染相关的临床和经济负担以及在老年人中观察到的抗菌素耐药性都要求在这些地区采取预防和治疗行动。重点总结肠外致病性大肠杆菌(ExPEC)是侵袭性疾病的主要原因,包括菌血症和败血症.有针对性的文献综述包括34项已发表的关于中国老年人/高危人群IED流行病学和临床经济负担的研究的最新数据,Japan,韩国,台湾,和澳大利亚。在韩国60岁以上的患者中,ExPEC占细菌相关侵袭性疾病的46.0%(1,238/2,692),其次是中国(44.4%(284/640)),台湾(39.0%(1,244/3,194)),和日本(18.1%(581/3,206)),而澳大利亚在一般成年人中报告了所有病原体中的ExPEC(54.7%(4,006/7,330))。研究报告说,住院时间和住院30天全因增加了9%至12%。这些因素以及在老年人中观察到的抗菌素耐药性要求在这些地区采取预防和治疗行动。该地区与ExPEC诱导的BSI或败血症相关的成本数据有限,但是有证据表明支出在增加。
UNASSIGNED: Extraintestinal Pathogenic Escherichia coli (ExPEC) is a leading cause of invasive disease, including bacteremia and sepsis. Invasive ExPEC disease (IED) has the potential to complicate the clinical treatment of other conditions and is associated with an increased mortality, hospitalization, and worse outcomes. Older adults and individuals with comorbid conditions are at higher risk of IED. ExPEC is of particular concern in the Asia Pacific region due to aging populations and rising antimicrobial resistance.
UNASSIGNED: This study aimed to synthesize most recent data on the epidemiology, clinical and economic burden of IED in the elderly/high risk populations in China, Japan, South Korea, Taiwan, and Australia.
UNASSIGNED: A targeted literature
review was conducted using Embase, Medline, as well as local scientific databases. We included studies published in English and local languages published from January 1, 2010 to October 7, 2020 that were relevant to the research objectives. Studies were narratively synthesized.
UNASSIGNED: A total of 1,047 studies were identified and 34 of them were included in this
review. ExPEC accounted for 46.0% (1,238/2,692) of bacteria-related invasive diseases in patients aged above 60 years in South Korea, followed by China (44.4% (284/640)), Taiwan (39.0% (1,244/3,194)), and Japan (18.1% (581/3,206)), while Australia reported ExPEC out of all pathogens (54.7% (4,006/7,330)) in general adults. Comorbidities such as diabetes or cancer were common in these patients. Studies reported increases in length-of-stay, and in-hospital 30-day all-cause mortality related to ExPEC associated bacteremia was between 9% to 12%. From a cost perspective, a 3-fold increase in sepsis-associated cost was reported in South Korea between 2005 and 2012. In Australia, antimicrobial resistance contributed to an additional cost of AUD $5.8 million per year (95% uncertainty interval [UI], $2.2-$11.2 million) in the treatment of bloodstream infections (BSIs).
UNASSIGNED: ExPEC was a major cause of blood stream infection across China, Japan, South Korea, Taiwan, and Australia. Both the clinical and economic burden associated to ExPEC infections as well as the antimicrobial resistance observed in the elderly call for preventive and curative actions in these regions.
Extraintestinal Pathogenic Escherichia coli (ExPEC) is a leading cause of invasive disease, including bacteremia and sepsis.A targeted literature
review included the most recent data from 34 published studies on the epidemiology and clinical and economic burden of IED in the elderly/high risk populations in China, Japan, South Korea, Taiwan, and Australia.ExPEC accounted for 46.0% (1,238/2,692) of bacteria-related invasive diseases in patients aged above 60 years in South Korea, followed by China (44.4% (284/640)), Taiwan (39.0% (1,244/3,194)), and Japan (18.1% (581/3,206)), while Australia reported ExPEC out of all pathogens (54.7% (4,006/7,330)) in general adults. Studies reported increases in length-of-stay and in-hospital 30-day all-cause between 9% to 12%. These factors, along with antimicrobial resistance observed in the elderly, call for preventive and curative actions in these regions.Data for costs associated with ExPEC induced BSI or sepsis in this region are limited, but evidence shows increasing expenditures.