背景:有一个假设,认为憩室病与代谢综合征(MS)或其组成部分之间存在关联,但是关于这个主题的数据不一致,尚未进行系统审查。我们进行了系统评价,以研究心脏代谢危险因素与憩室病之间的可能关联。
方法:通过PubMed进行了系统的文献检索,科克伦图书馆,和WebofScience于2022年12月收集必要的数据。审查了MS或个体代谢因素与无症状憩室病之间的关联的研究。
结果:在通过PubMed(477)确定的潜在相关文章中,科克伦图书馆(224),和WebofScience(296),29篇文章符合纳入标准,被用于这项工作。使用GRADE评估这些研究的研究质量。总的来说,6项研究被评为“非常低,“19项研究为”低,“和4项研究为”中等。“数据表明动脉高血压之间存在关联,肥胖,年轻患者的脂肪肝和憩室病。患者年龄似乎在憩室形成中起重要作用。有关糖尿病的数据尚无定论,可能需要进一步研究,具体取决于憩室的位置。
结论:根据综合数据,动脉高血压之间有联系,肥胖,和年轻患者的脂肪肝疾病。憩室的形成似乎受年龄和遗传因素的影响。该研究表明与心脏代谢危险因素有关。为了更好地了解代谢危险因素在无症状憩室病中的作用,基于这些发现,有针对性的研究是必要的.
BACKGROUND: There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic
review has not been performed. We conducted a systematic
review to investigate the possible association between cardiometabolic risk factors and diverticulosis.
METHODS: A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the
review.
RESULTS: Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as \"very low,\" 19 studies as \"low,\" and 4 studies as \"moderate.\" The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula.
CONCLUSIONS: Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.