■三联抗生素糊剂(TAP)是针对粪肠球菌的常用肛内药物。当传统牙科抗生素失效时,阿莫西林克拉维酸糊剂(ACP)被推荐为“回退”抗生素。比较TAP和ACP根除根管系统粪肠球菌的抗菌功效的文献很少;因此,这项体外研究的目的是评估和比较TAP和ACP作为根管内药物用于单根恒牙对粪肠球菌的抗菌效果.
■这在体外,实验研究评估了从提取的单根人类恒牙获得的60根样本。管径扩大,随后用粪肠球菌感染21天。用TAP处理4组污染样品,ACP,氢氧化钙(阳性对照),和盐水(阴性对照),分别。在1号结束时收集了牙屑,Seven,和第10天,并接种在琼脂平板。确定菌落形成单位的数量,并使用Kolmogorov-Smirnov和Shapiro-Wilks检验对数据进行统计分析。P<0.05被认为具有统计学意义。
■在所有3个测试日的平均粪肠球菌菌落计数表明,TAP表现出对细菌生长的最高抑制作用,其次是ACP,无统计学意义(P=1.00)。
■考虑到这项体外研究的局限性,研究结果表明,ACP可能是根管内治疗TAP的有效替代药物.
UNASSIGNED: Triple antibiotic paste (TAP) is the commonly used intracanal medicament against Enterococcus faecalis. Amoxicillin clavulanate paste (ACP) is recommended as a \"fall-back\" antibiotic when traditional dental antibiotics fail. Literature comparing the antimicrobial efficacy of TAP and ACP in eradicating E. faecalis from the root canal system is sparse; hence, this in vitro
study was conducted to evaluate and compare the antimicrobial efficacy of TAP and ACP as an intracanal medicament for endodontic treatment of single-rooted permanent teeth against E. faecalis.
UNASSIGNED: This in vitro, experimental
study evaluated 60 root samples obtained from extracted single-rooted human permanent teeth. The canal diameter was enlarged and subsequently infected with E. faecalis for 21 days. Four groups of the contaminated samples were treated with TAP, ACP, calcium hydroxide (positive control), and saline (negative control), respectively. Dentinal shavings were collected at the end of the 1st, 7th, and 10th day and inoculated in agar plates. The number of colony-forming units was determined, and the data were statistically analyzed using the Kolmogorov-Smirnov and Shapiro-Wilks test. P <0.05 was considered statistically significant.
UNASSIGNED: The mean number of E. faecalis colony counts across all 3 test days demonstrated that TAP exhibited the highest inhibition of bacterial growth, followed by ACP which is not statistically significant (P = 1.00).
UNASSIGNED: Considering the limitations of this in vitro
study, the findings suggest that ACP could be an effective alternative intracanal medicament to TAP for endodontic therapy.