Anogeisisssleiocarpus(DC。)Guill。&Perr。属于Combretaceae家族,被非洲传统医生和牲畜饲养者用于治疗非洲锥虫病等疾病,动物腹泻,哮喘,癌症,咳嗽,糖尿病,痢疾,勃起功能障碍,发烧,贾第鞭毛虫病,蠕虫酶,脑膜炎,月经失调,猴痘,口腔感染,脊髓灰质炎,镰状细胞性贫血,蛇咬,牙痛,泌尿血吸虫病,黄热病。这些活性中的一些与植物中多酚的存在有关,其中包括鞣花酸衍生物,黄酮类化合物,二苯乙烯,单宁,和三萜。已经从A.leiocarpus鉴定了几种生物活性分子。这些包括主要的活性成分,ellagitannins,鞣花酸衍生物,类黄酮和三萜。药理学研究证实其抗菌作用,抗真菌药,抗高血糖,抗高血压药,抗疟药,抗氧化,抗寄生虫,抗肿瘤和抗溃疡作用。茎皮主要进行了生物活性和植物化学研究,它是传统用户在种族医学调查中强调的最多的植物部分。体外和体内模型,揭示了对寄生虫引起蠕虫病的广泛药理作用,利什曼病,疟疾和锥虫病,已被用于研究来自A.leiocarpus的化合物。由于它在非洲传统医学和兽医实践中的用途,A.leiocarpus已经受到了研究人员的极大关注。当前的审查提供了关于A.leiocarpus的科学报告的全面概述和批判性评估,涵盖其传统用途,药理活性和植物化学。
Anogeissus leiocarpus (DC.) Guill. & Perr. belongs to the family Combretaceae and is used both by African traditional medical practitioners and livestock rearers to treat diseases such as African trypanosomiasis, animal diarrhoea, asthma, cancer, cough, diabetes, dysentery, erectile dysfunction, fever, giardiasis, helminthiases, meningitis, menstrual disorders, monkeypox, oral infections, poliomyelitis, sickle cell anaemia, snake bites, toothache, urinary schistosomiasis, and yellow fever. Some of these activities have been associated with the presence of polyphenols in the plant which include ellagic acid derivatives, flavonoids, stilbenes, tannins, and triterpenes. Several bioactive molecules have been identified from A. leiocarpus. These include the main active constituents, ellagitannins, ellagic acid derivates, flavonoids and triterpenes. Pharmacological studies have confirmed its antibacterial, antifungal, antihyperglycemic, antihypertensive, antimalarial, antioxidative, antiparasitic, antitumour and anti-ulcer effects. The stem bark has been investigated mainly for biological activities and phytochemistry, and it is the most mentioned plant part highlighted by the traditional users in ethnomedicinal surveys. In vitro and in vivo models, which revealed a wide range of pharmacological actions against parasites causing helminthiasis, leishmaniasis, malaria and trypanosomiasis, have been used to study compounds from A. leiocarpus. Because of its uses in African traditional medicine and veterinary practices, A. leiocarpus has received considerable attention from researchers. The current
review provides a comprehensive overview and critical appraisal of scientific reports on A. leiocarpus, covering its traditional uses, pharmacological activities and phytochemistry.