β-淀粉样蛋白(Aβ)的过度沉积与阿尔茨海默病(AD)的发生发展直接相关。目前AD的治疗仅减轻症状,而不是作用于Aβ,主要病因。因此,定期运动的抗淀粉样蛋白作用作为一种替代疗法已被广泛研究.这项系统评价和荟萃分析研究了定期体育锻炼在AD动物模型中的抗淀粉样蛋白作用。搜索是在电子数据库Pubmed上进行的,Embase,Scopus和WebofScience没有数据限制,并使用以下描述:“淀粉样β”(或老年斑或淀粉样斑块)和“运动”(或体育锻炼或训练)。使用系统工具评估偏倚风险。采用随机连续效应模型进行Meta分析。总共选择了36项研究,最多使用:转基因小鼠(n=29),跑步机训练,持续12周(间隔4至28周),速率为60分钟/天(间隔为30分钟,直到自由进入)和速度为12米/分钟(间隔为3.2至32米/分钟)。海马和皮质是最常见的研究区域。Meta分析显示Aβ减少,在未指定的同种型中作用更大Meta分析显示Aβ减少,在未指定的同种型中作用更大(N=4;SMD=-2.71,IC95%:-3.59,-1.84,p<0.00001,Q2=3.38,I2=11%)和Aβ1-42(N=21;SMD=-1.94,IC95%:-3.37,3001,关于培训,发现更大的效果是:1)游泳(N=4;SMD=-1.98,IC95%:-3,28--0,68,p=0.003,Q2=9.74,I2=69%),2)中等强度(N=4;SMD=-2.03%,IC95%:-3.31--0.75,p<0.005,Q2=12.68,I2=76%);3)持续时间长达六周(N=6;SMD=-2.35,IC95%:-1.55,p<0.00001,Q2=8.38,I2=40%SMD=1.48-59%,SMD=1.48-5然而,Aβ的减少与淀粉样途径的减少和非淀粉样途径的增加有关。因此,在AD的实验模型中,通过不同的信号通路在APP加工中产生积极的改变,有规律的体育锻炼证明了抗淀粉样蛋白的作用。
The excessive deposition of β-amyloid proteins (Aβ) is directly correlated with the establishment and development of Alzheimer\'s Disease (AD). Current treatments for AD only reduce symptoms instead of acting on Aβ, the primary etiological agent. Hence, the anti-amyloid effect of regular exercise has been widely investigated as an alternative therapy. This systematic
review and meta-analysis examined the anti-amyloid effect of regular physical exercise in animal models of AD. The search was conducted on the electronic databases Pubmed, Embase, Scopus and Web of Science without data limitation and using the following describers: \"amyloid beta\" (OR senile plaque OR amyloid plaque) and \"exercise\" (OR physical activity OR training). The risk of bias was evaluated using the SYRCLE\'s tool. Meta-analyses were conducted using models of random continuous effects. A total of 36 studies were selected and most used: transgenic mice (n = 29), treadmill training, duration of 12 weeks (interval of 4 to 28 weeks), rate of 60 min/day (interval of 30 min and up until free access) and speed of 12 m/min (interval of 3.2 to 32 m/min). The hippocampus and cortex were the most frequently investigated regions. Meta-analysis demonstrated a decrease in Aβ with greater effect in unspecified isoforms Meta-analysis demonstrated a decrease in Aβ with greater effect in unspecified isoforms (N = 4; SMD = -2.71, IC 95%: -3.59, -1.84, p < 0.00001, Q2 = 3.38, I2 = 11%) and Aβ1-42 (N = 21; SMD = -1.94, IC 95%: -2.37, -1.51, p < 0.00001, Q2 = 33,37, I2 = 40%). Concerning training, greater effect was found with: 1) swimming (N = 4; SMD = -1.98, IC 95%: -3,28 - -0,68, p = 0.003, Q2 = 9.74, I2 = 69%), 2) moderate intensity (N = 4; SMD = -2.03, IC 95%: -3.31 - -0.75, p < 0.005, Q2 = 12.68, I2 = 76%); 3) duration up to six weeks (N = 6; N = 6; SMD = -2.35, IC 95%: -3.15 - -1.55, p < 0.00001, Q2 = 8.38, I2 = 40%); 4) young animals (SMD = -2.00, IC 95%: -2.59 - -1.42, p < 0.00001, Q2 = 24.90, I2 = 52%); 5) in the amygdala region (N = 1; SMD = -8.56, IC 95%: -12.88 - -4.23, p = 0.0001) and females (N = 4; SMD = -2.14, IC 95%: -3.48 - -0.79, p = 0.002, Q2 = 10.31, I2 = 71%). However, the reduction of Aβ was associated with decrease of amyloidogenic pathway and increase of non-amyloidogenic. Hence, regular physical exercise demonstrated anti-amyloid effect in experimental models of AD through positive alterations in APP processing through different signaling pathways.