Abstract：
Alzheimer\'s disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors. The primary feature is the accumulation of amyloid-- beta and tau proteins, leading to neuroinflammation, synaptic dysfunction, oxidative stress, and neuronal loss. Conventional single-target therapies have shown limited effectiveness, prompting a shift toward simultaneously addressing multiple disease-related processes. Recent advancements in AD research underscore the potential of multifaceted therapies. This review explores strategies targeting both tau aggregation and amyloid-beta, along with interventions to alleviate neuroinflammation, enhance synaptic function, and reduce oxidative stress. In conclusion, the review emphasizes the growing importance of addressing various pathways in AD treatment. A holistic approach that targets different aspects of the disease holds promise for developing effective treatments and improving the quality of life for Alzheimer\'s patients and their caregivers.
摘要：
阿尔茨海默病（AD）的特点是复杂的病理景观，需要综合治疗方法。这篇简明的综述论文深入探讨了解决AD中多种机制的想法，总结发病机制的最新研究成果，危险因素，诊断,和治疗策略。AD的病因是多方面的,涉及遗传，环境,和生活方式因素。主要特征是淀粉样β和tau蛋白的积累，导致神经炎症，突触功能障碍,氧化应激，和神经元丢失。传统的单靶点治疗效果有限，促使转向同时解决多个疾病相关过程。AD研究的最新进展强调了多方面疗法的潜力。这篇综述探讨了针对tau聚集和淀粉样β的策略，以及缓解神经炎症的干预措施，增强突触功能，减少氧化应激。总之,该综述强调了在AD治疗中解决各种途径的重要性日益增加.针对该疾病不同方面的整体方法有望开发有效的治疗方法并改善阿尔茨海默病患者及其护理人员的生活质量。
