背景:甲状腺功能减退,以甲状腺激素产生不足为特征,影响了大量的全球人口,尤其是妇女和老人。最近的研究强调了甲状腺功能减退症与下丘脑-垂体-肾上腺(HPA)轴之间的相互作用,强调皮质醇在疾病的生理表现中的关键作用。
目的:本研究旨在评估甲状腺功能减退患者的血清皮质醇水平,检查这两个内分泌系统之间的复杂关系。通过探索皮质醇水平改变对甲状腺功能减退症的临床表现和进展的潜在影响,该研究旨在为增强诊断方法和制定更有效的治疗策略提供有价值的见解.
方法:在英迪拉·甘地医学科学研究所进行了一项横断面观察研究,评估65例甲状腺功能减退病例和65例年龄匹配的甲状腺功能正常对照。人口统计数据,病史,收集血液样本,和血清皮质醇,促甲状腺激素(TSH),三碘甲状腺原氨酸(T3),测量甲状腺素(T4)水平。该研究坚持道德考虑,并获得了机构批准。
结果:该研究包括65例甲状腺功能减退病例(56例女性,9名男性)和65名甲状腺功能正常对照。血清皮质醇与TSH、T4水平呈显著正相关。线性回归显示甲状腺功能减退症患者血清T4和T3水平与血清皮质醇呈负相关。TSH与皮质醇呈正相关。这些发现与以前的研究一致,提示甲状腺功能减退患者的潜在调节机制和代偿反应。
结论:研究结果强调了皮质醇与甲状腺功能之间的复杂相互作用,提示甲状腺功能减退症患者血清皮质醇与TSH水平之间存在直接关系。严重甲状腺功能减退症患者的皮质醇浓度升高,表明由HPA轴启动的潜在补偿机制。将血清皮质醇评估与常规甲状腺功能检查相结合,可以全面了解甲状腺功能减退的严重程度和进展,为患者护理提供更全面的方法。
结论:这项研究有助于了解血清皮质醇水平与甲状腺功能减退之间的复杂关系,强调需要进一步研究以揭示潜在的机制和治疗意义。全面的了解为甲状腺功能减退症患者提供更量身定制和有效的治疗策略的潜力。
BACKGROUND: Hypothyroidism, characterized by insufficient thyroid hormone production, affects a significant global population, particularly women and the elderly. Recent research has emphasized the interaction between hypothyroidism and the hypothalamic-pituitary-adrenal (HPA) axis, highlighting cortisol\'s crucial role in the disease\'s physiological manifestations.
OBJECTIVE: This
study aims to evaluate serum cortisol levels in hypothyroid patients, examining the intricate relationship between these two endocrine systems. By exploring the potential impact of altered cortisol levels on hypothyroidism\'s clinical presentation and progression, the study seeks to contribute valuable insights to enhance diagnostic approaches and develop more effective treatment strategies.
METHODS: A cross-sectional observational
study was conducted at the Indira Gandhi Institute of Medical Sciences, assessing 65 hypothyroid cases and 65 age-matched euthyroid controls. Demographic data, medical history, and blood samples were collected, and serum cortisol, thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) levels were measured. The
study adhered to ethical considerations and received institutional approval.
RESULTS: The
study included 65 hypothyroid cases (56 females, 9 males) and 65 euthyroid controls. Serum cortisol showed a significant correlation with TSH and T4 levels. Linear regression revealed a negative correlation between serum T4 and T3 levels and serum cortisol in hypothyroidism. A positive correlation was observed between TSH and cortisol. These findings align with previous studies, suggesting potential regulatory mechanisms and compensatory responses in hypothyroid patients.
CONCLUSIONS: The study\'s results emphasize the complex interaction between cortisol and thyroid function, suggesting a direct relationship between serum cortisol and TSH levels in hypothyroidism. Patients with severe hypothyroidism exhibited elevated cortisol concentrations, indicating a potential compensatory mechanism initiated by the HPA axis. Integrating serum cortisol assessment with conventional thyroid function tests could offer comprehensive insights into hypothyroidism severity and progression, providing a more holistic approach to patient care.
CONCLUSIONS: This
study contributes to understanding the complex relationship between serum cortisol levels and hypothyroidism, emphasizing the need for further research to uncover underlying mechanisms and therapeutic implications. A comprehensive understanding holds the potential for more tailored and effective treatment strategies for individuals with hypothyroidism.