目的:虽然腮腺恶性肿瘤并不常见,尽管如此,它们还是儿科人群发病率和死亡率的一个原因。很少有研究试图找出与它们的表达有关的差异,治疗,和生存。有必要了解这些变化,以改善对历史上代表性不足的群体的护理。
方法:回顾性队列研究。
方法:监测,流行病学,和最终结果(SEER)程序数据库。
方法:分析2000-2019年儿童腮腺恶性肿瘤患者。种族和种族被归类为非西班牙裔白人,非西班牙裔黑人,亚洲人,和西班牙裔进行多变量分析。结果包括诊断时的肿瘤大小和分期,生存,需要面部神经损伤.采用Kaplan-Meier分析进行生存分析。进行多变量逻辑回归以确定结果的预测因子。
结果:149例患者符合入选标准。按种族/族裔分层,非西班牙裔黑人(中位数23毫米,IQR15-33),亚洲(30毫米,14-32),和西班牙裔(23毫米,20-28)患者的肿瘤比非西班牙裔白人患者更大(18毫米,12-25,p=0.017)。疾病特异性生存率因治疗时间而异(log-rank,p=0.01),总体生存率因收入而异(p<0.001)。在多变量分析中,西班牙裔患者更容易出现面神经损伤(OR3.71,95CI1.25-11.6,p=0.020),与非西班牙裔白人患者相比,非西班牙裔黑人(OR3.37,0.95-11.6,=0.053)和亚洲人(OR5.67,1.46-22.2,p=0.011)患者表现出较大的肿瘤。
结论:儿童腮腺癌的表现和治疗存在种族和民族差异。识别这些差异可能有助于改善服务不足的患者人群的获取和结果。
方法:III.
OBJECTIVE: Although parotid gland malignancies are uncommon, they nevertheless represent a cause of morbidity and mortality in the pediatric population. Few studies have sought to identify disparities related to their presentation, treatment, and survival. There is a need to understand these variations to improve care for historically underrepresented groups.
METHODS: Retrospective Cohort
Study.
METHODS: Surveillance, Epidemiology, and End Results (SEER) Program Database.
METHODS: Analysis of pediatric patients with parotid gland malignancies between 2000 and 2019. Race and ethnicity were classified as Non-Hispanic White, Non-Hispanic Black, Asian, and Hispanic for multivariable analysis. Outcomes included tumor size and stage at diagnosis, survival, and need for facial nerve sacrifice. Kaplan-Meier analysis was used to analyze survival. Multivariable logistic regression was conducted to identify predictors of outcomes.
RESULTS: 149 patients met the criteria for inclusion. Stratified by race/ethnicity, Non-Hispanic Black (Median 23 mm, IQR 15-33), Asian (30 mm, 14-32), and Hispanic (23 mm, 20-28) patients had larger tumors at presentation than Non-Hispanic White patients (18 mm, 12-25, p = 0.017). Disease-specific survival differed by time-to-treatment (log-rank, p = 0.01) and overall survival differed by income (p < 0.001). On multivariable analysis, Hispanic patients were more likely to experience facial nerve sacrifice (OR 3.71, 95%CI 1.25-11.6, p = 0.020), and Non-Hispanic Black (OR 3.37, 0.95-11.6, = 0.053) and Asian (OR 5.67, 1.46-22.2, p = 0.011) patients presented with larger tumors compared to Non-Hispanic White patients.
CONCLUSIONS: Variations in presentation and treatment exist across race and ethnicity in pediatric parotid cancer. Identifying these disparities may help improve access and outcomes for underserved patient populations.
METHODS: III.