头颈部腺样囊性癌(ACC)的主要治疗方法是手术。很少,然而,ACC对神经周围和颅底的侵袭倾向可以排除明确的手术治疗。我们介绍了我们在质子放射治疗(RT)和同时进行的基于铂的化疗方面的经验。
9例无法切除的淋巴结阴性,非转移性头颈部ACC接受明确的质子RT和同步顺铂治疗。记录结果和毒性。对文献进行了系统回顾。
中位随访时间为27个月(范围,9.2-48.3个月)。四名患者在原发部位获得完全缓解,另外4名患者局部疾病稳定。只有1名患者出现局部疾病进展。4例患者有5例急性3级(G3)毒性,1例患者出现慢性G4视神经障碍。
我们的初步结果表明,质子RT和同步化疗是选择头颈部ACC患者的明确治疗选择。©2015威利期刊,公司。头颈38:E1472-E1480,2016。
The primary treatment for head and neck adenoid cystic carcinoma (ACC) is surgery. Infrequently, however, ACC\'s propensity for perineural and base of skull invasion can preclude definitive surgical management. We present our experience with proton radiation therapy (RT) and concurrent platinum-based chemotherapy.
Nine patients with unresectable node-negative, nonmetastatic head and neck ACC received definitive proton RT and concurrent cisplatin. Outcomes and toxicities were recorded. A systematic
review of the literature was performed.
Median follow-up was 27 months (range, 9.2-48.3 months). Four patients achieved complete response at the primary site, and an additional 4 patients achieved stabilization of local disease. Only 1 patient developed local disease progression. Four patients had 5 acute grade 3 (G3) toxicities, and 1 patient developed a chronic G4 optic nerve disorder.
Our preliminary results suggest proton RT and concurrent chemotherapy is a definitive treatment option for select patients with head and neck ACC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1472-E1480, 2016.