病原体侵入宿主细胞是导致感染的关键过程,这取决于肌动蛋白细胞骨架重排。宿主细胞中的Cofilin是最重要的肌动蛋白解聚因子之一,对几种病毒感染至关重要。细菌和真菌。病原微生物可以诱导宿主细胞肌动蛋白细胞骨架的双相重塑,伴随着cofilin磷酸化的变化,这导致cofilin活性的变化。通过突变调节宿主cofilin的活性,击倒,或过表达可有效抑制感染。现就宿主cofilin在感染过程中的功能及其可能的调控机制作一综述。
Invasion of pathogens into host cells is the key process to consequently induce the infection, which depends on the actin cytoskeleton rearrangement. Cofilin in the host cell is one of the most important actin depolymerization factor that is essential responsing to the infection of several viruses, bacteria and fungi. Pathogenic microbes can induce biphasic remodeling of the actin cytoskeleton in host cells, accompanied by changes of phosphorylation of cofilin, which results in changes of cofilin activity. The modulation of host cofilin activity by mutation, knockdown, or overexpression can effectively inhibit the infection. Here we
review the function and possible regulatory mechanism of host cofilin during the process of infection.