Acellular dermis

无细胞真皮
  • DOI:
    文章类型: Journal Article
    随着技术的发展,在美学领域追求可预测的植入物成功仍在继续。创造稳定的边缘骨和最佳的植入物周围粘膜环境是长期健康和美观的植入物治疗结果的基础。组织的稳定性取决于多种因素,包括用于创建种植体周围支持组织和维持组织体积的再生材料。本研究旨在描述一种技术,该技术结合了无翼的方法,以在美学区域中提取无望的牙齿,并使用无细胞真皮基质插入植入物,该无细胞真皮基质放置在包含创新的骨化胶原支架的冠状方面,旨在促进重要的天然骨的新生。该技术将微创方法与新型生物材料的应用相结合,该材料可稳定地增加牙龈厚度以及面部间隙中的骨骼填充。植入物和颊板之间的空间,以确保可预测的美学结果。提供了一系列病例,以证明手术技术和随访22个月的情况。治疗前后CBCT成像用于量化牙槽骨的稳定性或变化。在种植体周围表型中,治疗前后的口内扫描用于相同的目的。本病例系列提供了通过数字评估评估的稳定和美观的临床结果。
    The pursuit of predictable implant success in the aesthetic zone continues as technology develops. Creating stable marginal bone and an optimal peri-implant mucosal environment is the foundation for a long-term healthy and aesthetic implant treatment outcome. Tissue stability is dependent on multiple factors, including the regenerative materials used to create the peri-implant supporting tissues and maintain the tissue volume. The present study aims to describe a technique that combines a flapless approach to extract hopeless teeth in the aesthetic zone and implant insertion using an acellular dermal matrix placed to contain the coronal aspect of an innovative ossifying collagen scaffold designed to promote neoformation of vital native bone. This technique combines a minimally invasive approach with the application of a novel biomaterial that offers stable augmentation of the gingival thickness as well as bone fill in the facial gap, the space between the implant and the buccal plate, to ensure predictable aesthetic results. A collection of cases are presented to demonstrate the surgical technique and the situation over a follow-up period of 22 months. Pre- and post-treatment CBCT imaging were utilised to quantify the stability or changes noted in the alveolar bone, and pre-and post-treatment intraoral scanning were used for the same purpose in the peri-implant phenotype. This case series presents stable and aesthetic clinical outcomes evaluated through digital assessment.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    脱套损伤是由带有剪切机制的创伤引起的,通常仅次于在交通事故中被碾压。它的特点是皮肤和皮下组织撕脱,产生覆盖率赤字,在严重的情况下,患肢的损失。在这里,我们讨论了一个6岁男性被卡车碾过的案例,用橡胶轮胎直接撞击左下肢。进行清创术和手术清洁,并放置负压系统。随后,在创建可行的移植床后,将真皮基质和部分厚度的皮肤移植物作为覆盖。
    Degloving injuries are caused by trauma with shear mechanisms, usually secondary to being run over in traffic accidents. It is characterized by the avulsion of skin and subcutaneous tissue, generating coverage deficit, and in severe cases, loss of the affected limb. Herein, we discuss a case of a six-year-old male run over by a truck, receiving a direct impact on the left lower extremity with a rubber tire. Debridement and surgical cleaning were performed and a negative pressure system was placed. Subsequently, dermal matrix and partial-thickness skin grafts were placed as coverage after the creation of a viable grafting bed.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    背景:关于无细胞真皮基质(ADM)的改良冠状推进隧道(MCAT)治疗牙龈凹陷缺损(GRD)的结果存在有限的证据,尤其是当并发修复的宫颈病变时。因此,本病例报告的目的是评估MCAT联合ADM治疗与宫颈病变修复相关的上颌1型凹陷缺损(RT1)的短期和长期临床结局.
    方法:一名43岁女性患者,在左上颌骨有多个相邻的RT1凹陷,先前用悬垂的宫颈树脂修复体处理。通过仔细评估根覆盖率的诊断决定因素,去除异常的树脂修复体,用ADM治疗MCAT,以及为期10年的定期评估。治疗之后是完全的根覆盖,改善牙龈表型和完善的根覆盖美学评分。定期评估结果,并维持了10年以上的随访。
    结论:MCAT联合ADM是治疗多发性GRD合并宫颈修复的有效技术。获得并长期保持完整的根系覆盖率和出色的美学效果。本文受版权保护。保留所有权利一句话摘要:通过改良的冠状高级隧道和无细胞真皮基质,获得并维持了10年以上的完整根部覆盖,用于通过宫颈修复治疗多个牙龈凹陷。
    BACKGROUND: Limited evidence exists on the outcome of the modified coronally advanced tunnel (MCAT) with acellular dermal matrix (ADM) for the treatment of gingival recession defects (GRD) especially when complicated by restored cervical lesions. Therefore, the aim of this case report was to assess the short- and long-term clinical outcomes of maxillary Type 1 recession defects (RT1) associated with restored cervical lesions treated with MCAT with ADM.
    RESULTS: A 43-year-old female patient, presented with multiple adjacent RT1 recessions in the left maxilla, previously treated with overhanging cervical resin restorations. The case was approached with a careful evaluation of the diagnostic determinants of root coverage, removal of the aberrant resin restorations, treatment with MCAT with ADM, and periodical evaluation over a follow-up of 10 years. The treatment was followed by complete root coverage, improvement of gingival phenotype, and perfect root coverage esthetic score. Outcomes were periodically assessed and were maintained over 10 years of follow-up.
    CONCLUSIONS: MCAT with ADM is an effective technique for the treatment of multiple GRD complicated by cervical restorations. Complete root coverage and excellent esthetic outcomes were obtained and maintained in the long term.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • DOI:
    文章类型: Journal Article
    背景:创伤引起的胫骨前撕裂可能演变成慢性伤口,感染恶化,无需治疗。关于顽固性胫骨前溃疡的表现和治疗的文献数量有限。
    目的:本研究旨在对成功治疗顽固性胫骨前溃疡的手术治疗方法进行综述。
    方法:作者对胫骨前溃疡患者进行了回顾性病例回顾。在手术环境中,所有伤口都进行了积极的清创术。接下来,在放置一次来自胎牛真皮的抗微生物无细胞真皮组织基质之前,用针头开窗伤口,紧紧地粘在伤口床上。所有伤口均接受均匀的多层压缩敷料。
    结果:本研究包括3例胫骨前溃疡患者。尽管最初保守治疗超过6个月,但每个伤口都是机械创伤的结果,并恶化为难治性溃疡。所有溃疡均表现为蜂窝织炎的局部感染,血肿,和脓液的集合。伤口均无放射学骨髓炎的迹象。在清创和开窗后应用同种异体移植物导致伤口体积减少75%,66.7%,3例患者在28天内占50%。所有伤口均在4个月内成功愈合。
    结论:开窗方法和抗菌胎牛真皮基质的组合成功治愈了高危患者的难治疗性胫骨前溃疡。
    Pretibial lacerations resulting from trauma may evolve into chronic wounds with worsening infections without treatment. There is a limited amount of literature on the presentation and treatment of recalcitrant pretibial ulcerations.
    This study aims to provide a review of surgical treatment methodology that successfully managed recalcitrant pretibial ulcerations.
    The authors conducted a retrospective case review of patients with pretibial ulcerations. All wounds underwent aggressive debridement in the operative setting. Next, the wounds were fenestrated with a needle before placing one application of an antimicrobial acellular dermal tissue matrix derived from fetal bovine dermis, which was tightly adhered onto the wound bed. All wounds received a uniform multilayer compression dressing.
    Three patients with pretibial ulcerations were included in this study. Each wound was a result of mechanical trauma and deteriorated into a refractory ulceration despite initial conservative treatment for more than 6 months. All ulcers exhibited local infection of cellulitis, hematoma, and a collection of purulent fluid. None of the wounds had any signs of radiographic osteomyelitis. The application of the allograft following debridement and fenestration led to wound volume reduction by 75%, 66.7%, and 50% in 3 patients in 28 days. All wounds healed successfully within 4 months.
    The combination of a fenestration method and an antimicrobial fetal bovine dermal matrix successfully healed recalcitrant pretibial ulcerations in high-risk patients.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    背景:脐膨出是一种腹壁出生缺陷,巨大的脐膨出(GO)被定义为直径>5cm或含有突出的肝脏的脐膨出。GO通常是分阶段处理的,在这种情况下,在筒仓减少期间,在轴环和皮肤边缘的缝合部位发生开裂,使用合成可吸收网状物修复。
    方法:一名女婴出生36周,GO直径为8厘米,多个器官如小肠突出,盲肠,附录,还有整个肝脏.即使在GO筒仓的分阶段修复技术之后,筒仓环和皮肤边缘之间的伤口裂开,逐渐复位失败。
    方法:直径8厘米的GO,这是在产前超声检查中发现的。
    方法:修复缺损。小肠和肝脏仍然脱垂,有严重的粘连。粘连分解后,使用组织基质修复腹壁的肌肉层,但是皮肤无法修复。第二次手术后,缺损的伤口被尽可能地消毒。
    结果:腹壁缺损完全修复,无残留并发症。
    结论:使用无细胞猪真皮基质修复GO可以被认为是可行的治疗选择。
    BACKGROUND: An omphalocele is an abdominal wall birth defect, and a giant omphalocele (GO) is defined as an omphalocele having a diameter >5 cm or containing a herniated liver. GOs are usually treated in stages and in this case, during the silo reduction, dehiscence occurred at the suture site of the axis ring and skin edge, which was repaired using synthetic absorbable mesh.
    METHODS: A girl infant was born at 36 weeks with a GO of 8 cm diameter, and herniated multiple organs such as the small bowel, cecum, appendix, and the entire liver. Even after the staged repair technique for the GO silo, wound dehiscence between the ring of the silo and the edge of the skin occurred and gradual reduction failed.
    METHODS: A GO of 8 cm diameter, which was found during prenatal ultrasonography.
    METHODS: Revision was performed to repair the defect. The small bowel and liver were still prolapsed, and there were severe adhesions. After adhesiolysis, the muscle layer of the abdominal wall was repaired using the tissue matrix, but the skin could not be repaired. After the second operation, the defect wound was dressed as sterilely as possible.
    RESULTS: The abdominal wall defect was repaired completely; there were no residual complications.
    CONCLUSIONS: Repair of GOs using an acellular porcine dermal matrix can be considered a viable treatment option.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:下肢创伤的自我修复一直是研究热点之一。皮瓣和皮肤移植是下肢伤口重建的首选治疗方法。然而,这些治疗方法有很多缺点,如二次损伤,愈合质量差。近年来,无细胞真皮基质的使用已成为四肢溃疡的替代治疗选择.
    方法:本研究旨在探讨脱细胞真皮基质是否可以作为单一治疗方法来促进伤口愈合。7例下肢皮肤缺损暴露骨或肌腱,被Pelnac覆盖,这是一种由中国食品药品监督管理局批准的无细胞真皮基质产品。所有伤口均采用Pelnac治疗,不进行皮瓣和皮肤移植。每10天更换外部敷料。
    结果:最长20周后,所有的伤口都完全愈合了。在12个月的随访期间,没有患者在治疗区域出现皮肤磨损。所有患者均保持术后行走能力。所有患者对伤口愈合后的外观和感觉均满意。
    结论:这些发现可能意味着脱细胞真皮基质是一种新的方法,为治疗暴露骨或肌腱的下肢皮肤缺陷提供了机会。它也有可能闭合所有未感染的伤口,非缺血性,全层皮肤缺乏。
    BACKGROUND: Self-repair of lower limb wounds has always been one of the research hotspots. Flaps and skin graft are the preferred treatment for lower extremity wound reconstruction. However, these treatments have many disadvantages, such as secondary damage, poor healing quality. In recent years, the use of acellular dermal matrix has emerged as an alternative treatment option for extremity ulcers.
    METHODS: This study aimed to explore whether acellular dermal matrix can be used as a single treatment to promote wound healing. 7 patients with lower extremities cutaneous deficiency exposing bone or tendon, were covered by Pelnac, which was an acellular dermal matrix product approved by China Food and Drug Administration. All the wound was treated by Pelnac without flaps and skin graft. The external dressing was changed every 10 days.
    RESULTS: After a maximum of 20 weeks, all the wounds were completely healed. During the 12 months follow-up period none of the patients developed skin wear on the treatment area. All patients maintained their postoperative ambulatory ability. All patients were satisfied with the appearance and feeling after wound healing.
    CONCLUSIONS: These findings may mean acellular dermal matrix is a novel method offering opportunity for treatment of lower extremities cutaneous deficiency exposing bone or tendon. It also has the potential to close wounds of all uninfected, non-ischemic, full-thickness cutaneous deficiency.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    最近发布的市售新型猪脱细胞真皮基质(PADM)似乎具有可接受的生物学和临床特性,被认为是可接受的软组织替代材料。这三例病例报告的目的是通过隧道和PADM的不同变化以及术后3年获得的临床结果来介绍多发性牙龈凹陷的治疗方法。愈合结果显示只有轻微的手术并发症,与最小的患者报告的不适。术后3年,观察到理想的功能和美学结果.PADM似乎是一种有前途的异种软组织替代品。需要对更多的患者和缺陷进行进一步的研究以证实目前的发现。
    A recently released commercially available novel porcine acellular dermal matrix (PADM) appears to possess acceptable biologic and clinical properties to be considered as an acceptable soft tissue replacement material. The aim of these three case reports is to present the treatment of multiple gingival recession by means of different variations of the tunnel and PADM as well as the clinical outcomes obtained at 3 years postoperatively. The healing outcomes demonstrated only minor surgical complications, with minimal patient-reported discomfort. At 3 years postoperative, ideal functional and esthetic outcomes were observed. PADM seems to be a promising xenogeneic soft tissue substitute. Further studies with a higher number of patients and defects are necessary to confirm the present findings.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    暂无摘要。
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号