在4例表现为胰岛素瘤的临床病例中,通过一种新型的腹腔镜侧腹侧腹方法进行了微创胰腺部分切除术。所有4例病例均为年龄较大(7-9岁)和不同品种的雌性cast割犬(Wire毛腊肠犬,德国牧羊犬,杰克·罗素梗,和Boxer),都表现出了偶发的弱点,震颤,和/或癫痫发作。诊断是基于血浆葡萄糖水平低于参考范围,同时胰岛素水平升高或正常。根据腹部的三相对比增强计算机断层扫描结果,考虑了腹腔镜方法,发现位于右胰腺肢或左胰腺肢的胰腺肿块,不怀疑转移。腹腔镜手术没有任何重大并发症,在所有情况下,围手术期血糖升高至(超)正常水平。组织病理学报告将肿块定性为神经内分泌癌,结合临床表现,该肿瘤进一步定义为胰岛素瘤.重症监护室的术后护理持续时间短,并且所有动物在手术后1.5至2.5天之间的临床正常和血糖正常出院。在短期随访中,没有狗表现出临床异常,都从外科手术中恢复得很好,血糖水平保持在正常范围内。在长期随访中,2例患者在撰写本文时保持临床正常,手术后564天和1,211天,1只狗在246天后出现低血糖复发,并在手术673天后因疾病进展而安乐死,1,028天后,由于与胰岛素瘤无关的原因,1条狗被安乐死。诊断后生存时间为599至1,232天。考虑到胰岛素瘤患者的高度转移性和完全腹腔镜分期的难度,在考虑腹腔镜手术时,需要进行彻底的术前疾病分期.此病例系列显示了一种新颖的腹腔镜侧腹方法在狗的左右部分胰腺切除术中的可行性。此外,在这些胰岛素瘤患者中,适当的病例选择导致了良好的预后。
A minimally invasive partial pancreatectomy was performed through a novel laparoscopic lateral flank approach in sternal-oblique recumbency in four clinical cases presented with an insulinoma. All four cases were female castrated dogs of older age (range 7-9 years) and different breeds (Wire haired dachshund, German shepherd, Jack Russel terrier, and Boxer), and all presented with episodic weakness, tremors, and/or seizures. The diagnosis was based on plasma glucose level below reference range with concomitant increased or normal insulin level. A laparoscopic approach was considered based on triple-phase contrast-enhanced computed tomography findings of the abdomen, revealing a pancreatic mass situated in the right pancreatic limb or left pancreatic limb without suspicion of metastasis. Laparoscopic procedures were performed without any major complications, and peri-operative glycemia increased to (supra-)normal levels in all cases. Histopathologic
reports qualified the masses as neuroendocrine carcinomas, and in conjunction with the clinical picture, this neoplasia was further defined as insulinoma. Post-operative care in an intensive care unit was of short duration, and all animals were discharged being clinically normal and normoglycemic in between 1.5 and 2.5-day post-surgery. At short-term follow-up, no dogs showed clinical abnormalities, all recovered well from the surgical procedure, and blood glucose levels remained in the normal range. During long-term follow-up, 2 cases remained clinically normal at the time of writing, 564 and 1,211 days after surgery, 1 dog had recurrence of hypoglycemic episodes after 246 days and was euthanized after 673 days of surgery due to progressing disease, and 1 dog was euthanized after 1,028 days of surgery due to reasons unrelated to the insulinoma. Survival times ranged from 599 to 1,232 days after diagnosis. Considering the highly metastatic nature and difficulty of full laparoscopic staging of insulinoma patients, thorough pre-operative disease staging is warranted when considering a laparoscopic approach. This
case series shows the feasibility of a novel laparoscopic flank approach for right and left partial pancreatectomy in dogs. Furthermore, proper
case selection resulted in favorable outcome in these insulinoma patients.