Abstract：
BACKGROUND: Solid organ transplantation (SOT) offers improved long-term survival for youth with end-stage organ disease. From a neurodevelopmental, cognitive, and academic perspective, children with solid organ transplant have a number of unique risk factors. While cognitive functioning may improve post-transplantation, it is important to understand the trajectory of neurocognitive development starting in transplant candidacy to evaluate the implications of early deficits.
OBJECTIVE: The aim of this paper is to describe the neurocognitive risks and long-term implications for adolescent transplant recipients.
METHODS: This paper provides an overview of neurocognitive functioning in youth with end-stage organ dysfunction with discussion of implications for adolescent transplant recipients.
RESULTS: Post-transplant, adolescent, and young adult solid organ transplant recipients exhibit significant levels of executive dysfunction, with implications for decision-making, regimen adherence, and transition to adult transplant care.
CONCLUSIONS: Transplantation may reduce the risk for poor long-term neurocognitive effects, yet adolescent transplant recipients remain at increased risk, particularly in executive functioning, which has implications for adherence and transition to adulthood. Baseline and follow-up assessments for youth with end-stage organ disease and transplant are important for the monitoring of neurocognitive development and may be used to mitigate risk for low adherence to post-transplantation treatment regimens and reduce barriers to transitioning to adult transplant care.
OBJECTIVE: The aim of this paper is to describe the neurocognitive risks and long-term implications for adolescent transplant recipients.
METHODS: This paper provides an overview of neurocognitive functioning in youth with end-stage organ dysfunction with discussion of implications for adolescent transplant recipients.
RESULTS: Post-transplant, adolescent, and young adult solid organ transplant recipients exhibit significant levels of executive dysfunction, with implications for decision-making, regimen adherence, and transition to adult transplant care.
CONCLUSIONS: Transplantation may reduce the risk for poor long-term neurocognitive effects, yet adolescent transplant recipients remain at increased risk, particularly in executive functioning, which has implications for adherence and transition to adulthood. Baseline and follow-up assessments for youth with end-stage organ disease and transplant are important for the monitoring of neurocognitive development and may be used to mitigate risk for low adherence to post-transplantation treatment regimens and reduce barriers to transitioning to adult transplant care.
摘要：
背景：实体器官移植（SOT）为患有终末期器官疾病的年轻人提供了改善的长期生存。从神经发育中，认知，和学术观点，接受实体器官移植的儿童有许多独特的危险因素.虽然认知功能可以改善移植后，重要的是要了解从移植候选人资格开始的神经认知发展轨迹,以评估早期缺陷的影响.
目的：本文的目的是描述青少年移植受者的神经认知风险和长期影响。
方法：本文概述了患有终末期器官功能障碍的青少年神经认知功能，并讨论了对青少年移植受体的影响。
结果：移植后，青春期,年轻的成人实体器官移植受者表现出明显的执行功能障碍，对决策有影响，方案依从性，过渡到成人移植护理。
结论：移植可以降低长期神经认知效果差的风险，然而，青少年移植接受者的风险仍然增加，特别是在执行功能方面，这对坚持和过渡到成年有影响。对患有终末期器官疾病和移植的年轻人的基线和后续评估对于监测神经认知发育很重要，可用于减轻对移植后治疗方案的低依从性的风险，并减少过渡到成人移植护理的障碍。
目的：本文的目的是描述青少年移植受者的神经认知风险和长期影响。
方法：本文概述了患有终末期器官功能障碍的青少年神经认知功能，并讨论了对青少年移植受体的影响。
结果：移植后，青春期,年轻的成人实体器官移植受者表现出明显的执行功能障碍，对决策有影响，方案依从性，过渡到成人移植护理。
结论：移植可以降低长期神经认知效果差的风险，然而，青少年移植接受者的风险仍然增加，特别是在执行功能方面，这对坚持和过渡到成年有影响。对患有终末期器官疾病和移植的年轻人的基线和后续评估对于监测神经认知发育很重要，可用于减轻对移植后治疗方案的低依从性的风险，并减少过渡到成人移植护理的障碍。
