PDF(Pubmed)
Abstract：
In the nervous system, alternative RNA processing is particularly prevalent, which results in the expression of thousands of transcript variants found in no other tissue. Neuron-specific RNA-binding proteins co-transcriptionally regulate alternative splicing, alternative polyadenylation, and RNA editing, thereby shaping the RNA identity of nervous system cells. Recent evidence suggests that interactions between RNA-binding proteins and cis-regulatory elements such as promoters and enhancers play a role in the determination of neuron-specific expression profiles. Here, we discuss possible mechanisms through which transcription and RNA processing cross-talk to generate the uniquely complex neuronal transcriptome, with a focus on alternative 3\'-end formation.
摘要：
在神经系统中，替代RNA加工特别普遍，这导致在其他组织中没有发现的数千个转录变体的表达。神经元特异性RNA结合蛋白共转录调节可变剪接，选择性聚腺苷酸化，和RNA编辑，从而塑造神经系统细胞的RNA身份。最近的证据表明，RNA结合蛋白与顺式调节元件如启动子和增强子之间的相互作用在确定神经元特异性表达谱中起作用。这里,我们讨论了转录和RNA加工交叉对话产生独特复杂的神经元转录组的可能机制，专注于替代3'端编队。
