Early COVID-19 XBB.1.5 Vaccine Effectiveness Against Hospitalisation Among Adults Targeted for Vaccination, VEBIS Hospital Network, Europe, October 2023-January 2024.

早期 COVID - 19 XBB.1. 5 疫苗对目标疫苗接种的成年人住院的有效性 ，VEBIS 医院网络,欧洲,2023 年 10 月 - 2024 年 1 月。

• 影响指数: 5.606
• 发表时间: 2024 Aug
• 来源期刊: Influenza Other Respir Viruses
• DOI: 10.1111/irv.13360
• PMID: 39145535
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Antunes L,Mazagatos C,Martínez-Baz I,Naesens R,Borg ML,Petrović G,Fatukasi T,Jancoriene L,Machado A,Oroszi B,Husa P,Lazar M,Dürrwald R,Howard J,Melo A,Pérez-Gimeno G,Castilla J,Bernaert E,Džiugytė A,Makarić ZL,Fitzgerald M,Mickienė A,Gomez V,Túri G,Součková L,Marin A,Tolksdorf K,Nicolay N,Rose AMC,

关键词: COVID‐19 XBB.1.5 vaccine; Europe; SARS‐CoV‐2 hospitalisation; vaccine effectiveness

Mesh: Humans; Hospitalization / statistics & numerical data; COVID-19 / prevention & control epidemiology; COVID-19 Vaccines / immunology administration & dosage; Aged; Europe / epidemiology; Female; Male; Middle Aged; Adult; Case-Control Studies; SARS-CoV-2 / immunology; Vaccine Efficacy / statistics & numerical data; Vaccination / statistics & numerical data; Young Adult; Aged, 80 and over; Adolescent

Abstract

We conducted a multicentre test-negative case-control study covering the period from October 2023 to January 2024 among adult patients aged ≥ 18 years hospitalised with severe acute respiratory infection in Europe. We provide early estimates of the effectiveness of the newly adapted XBB.1.5 COVID-19 vaccines against PCR-confirmed SARS-CoV-2 hospitalisation. Vaccine effectiveness was 49% overall, ranging between 69% at 14-29 days and 40% at 60-105 days post vaccination. The adapted XBB.1.5 COVID-19 vaccines conferred protection against COVID-19 hospitalisation in the first 3.5 months post vaccination, with VE > 70% in older adults (≥ 65 years) up to 1 month post vaccination.

摘要

我们进行了一项多中心测试阴性病例对照研究，涵盖2023年10月至2024年1月，在欧洲因严重急性呼吸道感染住院的年龄≥18岁的成年患者中。我们提供了新适应的XBB.1.5COVID-19疫苗对PCR确认的SARS-CoV-2住院的有效性的早期估计。疫苗总有效率为49%，疫苗接种后14-29天的69%和60-105天的40%之间。适应的XBB.1.5COVID-19疫苗在疫苗接种后的前3.5个月内提供了预防COVID-19住院的保护，在疫苗接种后1个月内，老年人(≥65岁)的VE>70%。