PDF(Pubmed)
Abstract：
UNASSIGNED: Genetically high-risk children carry indicators of brain dysfunctions that adult patients with schizophrenia or bipolar disorder display. The accumulation of risk indicators would have a higher predictive value of a later transition to psychosis or mood disorder than each individual risk indicator. Since more than 50% of adult patients report having been exposed to childhood trauma, we investigated whether exposure to trauma during childhood was associated with the early accumulation of risk indicators in youths at genetic risk.
UNASSIGNED: We first inspected the characteristics of childhood trauma in 200 young offspring (51% male) born to a parent affected by DSM-IV schizophrenia, bipolar disorder, or major depressive disorder. A subsample of 109 offspring (51% male) had measurements on four risk indicators: cognitive impairments, psychotic-like experiences, nonpsychotic nonmood childhood DSM diagnoses, poor global functioning. Trauma was assessed from direct interviews and reviews of lifetime medical and school records of offspring.
UNASSIGNED: Trauma was present in 86 of the 200 offspring (43%). The relative risk of accumulating risk indicators in offspring exposed to trauma was 3.33 (95% CI 1.50, 7.36), but more pronounced in males (RR = 4.64, 95% CI 1.71, 12.6) than females (RR = 2.01, 95% CI 0.54, 7.58).
UNASSIGNED: Childhood trauma would be related to the accumulation of developmental precursors of major psychiatric disorders and more so in young boys at high genetic risk. Our findings may provide leads for interventions targeting the early mechanisms underlying the established relation between childhood trauma and adult psychiatric disorders.
UNASSIGNED: We first inspected the characteristics of childhood trauma in 200 young offspring (51% male) born to a parent affected by DSM-IV schizophrenia, bipolar disorder, or major depressive disorder. A subsample of 109 offspring (51% male) had measurements on four risk indicators: cognitive impairments, psychotic-like experiences, nonpsychotic nonmood childhood DSM diagnoses, poor global functioning. Trauma was assessed from direct interviews and reviews of lifetime medical and school records of offspring.
UNASSIGNED: Trauma was present in 86 of the 200 offspring (43%). The relative risk of accumulating risk indicators in offspring exposed to trauma was 3.33 (95% CI 1.50, 7.36), but more pronounced in males (RR = 4.64, 95% CI 1.71, 12.6) than females (RR = 2.01, 95% CI 0.54, 7.58).
UNASSIGNED: Childhood trauma would be related to the accumulation of developmental precursors of major psychiatric disorders and more so in young boys at high genetic risk. Our findings may provide leads for interventions targeting the early mechanisms underlying the established relation between childhood trauma and adult psychiatric disorders.
摘要：
■遗传高危儿童携带成年精神分裂症或躁郁症患者表现出的脑功能障碍指标。与每个单独的风险指标相比，风险指标的积累对以后过渡到精神病或情绪障碍的预测价值更高。由于超过50%的成年患者报告曾遭受过童年创伤，我们调查了在有遗传风险的青少年中,儿童期创伤暴露是否与风险指标的早期积累相关.
■我们首先检查了受DSM-IV精神分裂症影响的父母所生的200个年轻后代（51％为男性）的童年创伤特征，双相情感障碍,或重度抑郁症。109个后代的子样本（51％为男性）对四个风险指标进行了测量：认知障碍，类似精神病的经历，非精神病性非情绪儿童期DSM诊断，全球功能不佳。创伤是通过直接访谈和对后代的终生医疗和学校记录的回顾来评估的。
■200个后代中有86个（43％）存在创伤。暴露于创伤的后代中累积风险指标的相对风险为3.33（95％CI1.50，7.36），但男性（RR=4.64，95%CI1.71，12.6）比女性（RR=2.01，95%CI0.54，7.58）更明显。
儿童创伤与主要精神疾病的发育前兆的积累有关，在遗传风险较高的年轻男孩中更是如此。我们的发现可能为针对儿童创伤与成人精神疾病之间既定关系的早期机制的干预措施提供线索。
■我们首先检查了受DSM-IV精神分裂症影响的父母所生的200个年轻后代（51％为男性）的童年创伤特征，双相情感障碍,或重度抑郁症。109个后代的子样本（51％为男性）对四个风险指标进行了测量：认知障碍，类似精神病的经历，非精神病性非情绪儿童期DSM诊断，全球功能不佳。创伤是通过直接访谈和对后代的终生医疗和学校记录的回顾来评估的。
■200个后代中有86个（43％）存在创伤。暴露于创伤的后代中累积风险指标的相对风险为3.33（95％CI1.50，7.36），但男性（RR=4.64，95%CI1.71，12.6）比女性（RR=2.01，95%CI0.54，7.58）更明显。
儿童创伤与主要精神疾病的发育前兆的积累有关，在遗传风险较高的年轻男孩中更是如此。我们的发现可能为针对儿童创伤与成人精神疾病之间既定关系的早期机制的干预措施提供线索。
