通过 cryo - EM 揭示的 Pol θ 解旋酶小分子抑制剂的结构基础。
Mesh : Cryoelectron Microscopy Humans DNA Helicases / metabolism chemistry genetics antagonists & inhibitors DNA-Directed DNA Polymerase / metabolism chemistry genetics DNA Polymerase theta BRCA2 Protein / metabolism genetics chemistry BRCA1 Protein / metabolism genetics chemistry Piperazines / pharmacology chemistry Cell Line, Tumor Phthalazines / pharmacology chemistry Enzyme Inhibitors / pharmacology chemistry Models, Molecular Adenosine Triphosphatases / metabolism antagonists & inhibitors Protein Binding
来 源:
DOI:10.1038/s41467-024-51351-4
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