非小细胞肺癌通过新型噻唑 - 三唑杂种作为双重 T 型 CCB / MMP - 9 抑制剂对铂类化疗增敏。
关键词: MMP-9 T-type calcium channel adjuvant therapy cisplatin lung cancer
Mesh : Humans Carcinoma, Non-Small-Cell Lung / drug therapy pathology metabolism Lung Neoplasms / drug therapy pathology metabolism Antineoplastic Agents / pharmacology chemistry chemical synthesis Drug Screening Assays, Antitumor Triazoles / chemistry pharmacology chemical synthesis Structure-Activity Relationship Matrix Metalloproteinase 9 / metabolism Dose-Response Relationship, Drug Thiazoles / chemistry pharmacology chemical synthesis Molecular Structure Cell Proliferation / drug effects Matrix Metalloproteinase Inhibitors / pharmacology chemistry chemical synthesis Cisplatin / pharmacology chemistry Calcium Channels, T-Type / metabolism
来 源:
DOI:10.1080/14756366.2024.2388209
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